Patients characteristics
| Characteristic . | Patient no. . | ||||||
|---|---|---|---|---|---|---|---|
| 1 . | 2 . | 3 . | 4 . | 5 . | 6 . | 7 . | |
| Age, y | 9 | 2 | 13 | 13 | 3 | 3 | 2 |
| Subtype | T | T | pc-B | pc-B | T | pc-B | pc-B |
| Blast, d0 | 207 | 338 | 70 | 69 | 34 | 0.1 | 69 |
| Blast, d8 | 127 | 1.8 | 5.7 | 1.8 | 0.7 | 0 | 0 |
| Pred. resp* | poor | poor | poor | poor | good | good | good |
| BM blast d0 | 92% | 95% | n/a | 99% | 87% | 98% | 96% |
| MRD† | HR | non-HR | HR | non-HR | non-HR | non-HR | non-HR |
| Characteristic . | Patient no. . | ||||||
|---|---|---|---|---|---|---|---|
| 1 . | 2 . | 3 . | 4 . | 5 . | 6 . | 7 . | |
| Age, y | 9 | 2 | 13 | 13 | 3 | 3 | 2 |
| Subtype | T | T | pc-B | pc-B | T | pc-B | pc-B |
| Blast, d0 | 207 | 338 | 70 | 69 | 34 | 0.1 | 69 |
| Blast, d8 | 127 | 1.8 | 5.7 | 1.8 | 0.7 | 0 | 0 |
| Pred. resp* | poor | poor | poor | poor | good | good | good |
| BM blast d0 | 92% | 95% | n/a | 99% | 87% | 98% | 96% |
| MRD† | HR | non-HR | HR | non-HR | non-HR | non-HR | non-HR |
Blast in Giga/L
T indicates T-ALL; pc-B, precursor-B-ALL; Pred. resp, prednisone response; BM, bone marrow; HR, high risk and n/a, not available.
Prednisone poor response is defined as more then 1000 blasts/μL at day 8 of prednisone therapy.
HR MRD is defined as an MRD load of 10−3 or greater at week 12 of treatment.