Multivariate analysis of outcomes after haploidentical transplantation for patients with high-risk acute leukemia in remission at transplantation
| Diagnosis . | Outcomes . | ||
|---|---|---|---|
| Transplantation-related mortality . | RI . | Leukemia-free survival . | |
| AML | Type of donor (parents or siblings):* RR = 0.44; 95% CI, 0.22-0.87; P = .018 | No risk factor | Type of donor (parents or siblings):† RR = 1.81; 95% CI, 1.01-3.22; P = .045 |
| ALL | Donor's negative CMV serology to a patient's negative CMV serology:‡ RR = 0.3; 95% CI, 0.08-0.84; P = .002 | No risk factor | Donor's negative CMV serology to a patient's negative CMV serology:§ RR = 2.6; 95% CI, 1.14-6.07; P = .02 |
| Diagnosis . | Outcomes . | ||
|---|---|---|---|
| Transplantation-related mortality . | RI . | Leukemia-free survival . | |
| AML | Type of donor (parents or siblings):* RR = 0.44; 95% CI, 0.22-0.87; P = .018 | No risk factor | Type of donor (parents or siblings):† RR = 1.81; 95% CI, 1.01-3.22; P = .045 |
| ALL | Donor's negative CMV serology to a patient's negative CMV serology:‡ RR = 0.3; 95% CI, 0.08-0.84; P = .002 | No risk factor | Donor's negative CMV serology to a patient's negative CMV serology:§ RR = 2.6; 95% CI, 1.14-6.07; P = .02 |
Other variables included in the model if P < .20.
RI indicates relapse; CMV, cytomegalovirus; RR, relative risk; and 95% CI, 95% confidence interval.
Type of donor, site of transplantation, status of the disease at transplantation, and number of previous transplantations.
Patient CMV serology, female donor to male recipient, type of donor, site of transplantation, and status of the disease at transplantation.
Recipient's age, year of transplantation, status of the disease at transplantation, and donor CMV/patient CMV.
Recipient's age, year of transplantation (RR = 1.9; 95% CI, 0.98-3.8; P = .06), status of the disease at transplantation, and donor CMV/patient CMV.