Worst toxicity experienced (CTC grade) during the treatment (for 109 patients who received at least 1 cycle of protocol treatment) in dmCODOX-M/IVAC study
| . | Low risk, N = 33 . | High risk, N = 76 . | Total, N = 109 . | |||
|---|---|---|---|---|---|---|
| n . | % . | n . | % . | n . | % . | |
| WBC | ||||||
| Grade 3 | 1 | 3 | 0 | 0 | 1 | 1 |
| Grade 4 | 32 | 97 | 75* | 99 | 107 | 98 |
| Neutropenic fever | ||||||
| Grade 3 | 20 | 61 | 67 | 88 | 87 | 80 |
| Neutrophil count | ||||||
| Grade 3 | 0 | 0 | 1 | 1 | 1 | 1 |
| Grade 4 | 32 | 97 | 75 | 99 | 107 | 98 |
| Platelets | ||||||
| Grade 3 | 5 | 15 | 1 | 1 | 6 | 6 |
| Grade 4 | 14 | 42 | 73 | 96 | 87 | 80 |
| Mucositis | ||||||
| Grade 3 | 10 | 31 | 29 | 38 | 39 | 36 |
| Grade 4 | 2 | 6 | 8 | 11 | 10 | 9 |
| Unknown | 1 | 0 | 1 | |||
| Neuropath, sensory/motor | ||||||
| Grade 3 | 3 | 10 | 3 | 4 | 6 | 6 |
| Grade 4 | 0 | 0 | 2 | 3 | 2 | 2 |
| Unknown | 3 | 0 | 3 | |||
| . | Low risk, N = 33 . | High risk, N = 76 . | Total, N = 109 . | |||
|---|---|---|---|---|---|---|
| n . | % . | n . | % . | n . | % . | |
| WBC | ||||||
| Grade 3 | 1 | 3 | 0 | 0 | 1 | 1 |
| Grade 4 | 32 | 97 | 75* | 99 | 107 | 98 |
| Neutropenic fever | ||||||
| Grade 3 | 20 | 61 | 67 | 88 | 87 | 80 |
| Neutrophil count | ||||||
| Grade 3 | 0 | 0 | 1 | 1 | 1 | 1 |
| Grade 4 | 32 | 97 | 75 | 99 | 107 | 98 |
| Platelets | ||||||
| Grade 3 | 5 | 15 | 1 | 1 | 6 | 6 |
| Grade 4 | 14 | 42 | 73 | 96 | 87 | 80 |
| Mucositis | ||||||
| Grade 3 | 10 | 31 | 29 | 38 | 39 | 36 |
| Grade 4 | 2 | 6 | 8 | 11 | 10 | 9 |
| Unknown | 1 | 0 | 1 | |||
| Neuropath, sensory/motor | ||||||
| Grade 3 | 3 | 10 | 3 | 4 | 6 | 6 |
| Grade 4 | 0 | 0 | 2 | 3 | 2 | 2 |
| Unknown | 3 | 0 | 3 | |||
One patient did not report grade 3/4 leukopenia but received only part of cycle 1 dmCODOX-M prior to disease progression.