Comparison of apoptosis-inducing effects of quercetin and bortezomib
| Property . | Quercetin . | Bortezomib . | References . |
|---|---|---|---|
| Compound | Flavonoid | Boronic dipeptide | 1, 12 |
| Proteasome binding site | Inhibition on β5 subunit | Inhibition on β5 subunit | 15 |
| ROS | Inhibition | Generation | 26, 29 |
| NF-κB | Inhibition | Inhibition | 43 |
| Bax | Activation | Activation | 15, 43 |
| Caspase-3 | Activation | Activation | 29, 44 |
| Cell cycle | G2/M arrest | G2/M arrest | 45, 46 |
| Proliferation | Inhibition | Inhibition | 45, 46 |
| Property . | Quercetin . | Bortezomib . | References . |
|---|---|---|---|
| Compound | Flavonoid | Boronic dipeptide | 1, 12 |
| Proteasome binding site | Inhibition on β5 subunit | Inhibition on β5 subunit | 15 |
| ROS | Inhibition | Generation | 26, 29 |
| NF-κB | Inhibition | Inhibition | 43 |
| Bax | Activation | Activation | 15, 43 |
| Caspase-3 | Activation | Activation | 29, 44 |
| Cell cycle | G2/M arrest | G2/M arrest | 45, 46 |
| Proliferation | Inhibition | Inhibition | 45, 46 |