Characteristics of MPN patients, controls, and first-degree relatives
| Variable . | MPN patients . | Controls . | ||||
|---|---|---|---|---|---|---|
| PV . | ET . | MF . | MPN NOS . | Any MPN . | ||
| No. (%) of patients | 6217 (100) | 2838 (100) | 1172 (100) | 812 (100) | 11 039 (100) | 43 550 (100) |
| Male, sex, n (%) | 3078 (49.5) | 1214 (42.8) | 644 (55.0) | 401 (49.4) | 5337 (48.4) | 21 152 (48.6) |
| Age at diagnosis, y [mean (range)] | 66 (3-97) | 66 (1-98) | 69 (16-93) | 71 (20-97) | 67 (1-90) | 67 (1-98) |
| Age group at diagnosis, no. (%) | ||||||
| Younger than 40 y | 208 (3.4) | 212 (7.5) | 22 (1.9) | 18 (2.2) | 460 (4.2) | 1840 (4.2) |
| 40-49 y | 443 (7.1) | 253 (8.9) | 57 (4.9) | 41 (5.1) | 794 (7.2) | 3174 (7.3) |
| 50-59 y | 1037 (16.7) | 385 (13.6) | 150 (12.8) | 74 (9.1) | 1646 (14.9) | 6572 (15.0) |
| 60-69 y | 1661 (26.7) | 580 (20.4) | 310 (26.4) | 177 (21.8) | 2728 (24.7) | 10 826 (24.9) |
| 70-79 y | 1968 (31.6) | 865 (30.5) | 431 (36.8) | 269 (33.1) | 3533 (32.0) | 13 834 (31.8) |
| Older than 80 y | 900 (14.5) | 543 (19.1) | 202 (17.2) | 233 (28.7) | 1878 (17.1) | 7304 (16.8) |
| Year of birth, mean (range) | 1917 (1872-1993) | 1926 (1875-1990) | 1919 (1879-1979) | 1927 (1901-1982) | 1920 (1872-1993) | 1921 (1872-1993) |
| Calendar year of diagnosis, no. (%) | ||||||
| 1958-1965 | 590 (9.5) | 48 (1.7) | 1 (0.1) | — | 639 (5.8) | 2556 (5.9) |
| 1966-1975 | 1172 (18.9) | 145 (5.1) | 124 (10.6) | — | 1441 (13.1) | 5747 (13.2) |
| 1976-1985 | 1364 (21.9) | 201 (7.1) | 328 (28.0) | — | 1893 (17.2) | 7443 (17.1) |
| 1986-1995 | 1527 (25.5) | 1542 (54.3) | 412 (35.2) | 159 (19.6) | 3640 (32.9) | 14 250 (32.7) |
| 1996-2005 | 1564 (25.2) | 902 (31.8) | 307 (26.2) | 653 (80.4) | 3426 (31.0) | 13 554 (31.1) |
| Data source, no. (%) | ||||||
| Cancer Registry | 5491 (88.3) | 2367 (83.4) | 1030 (87.9) | 812 (100) | 3998 (87.9) | 38 260 (87.8) |
| Local hospitals | 726 (11.7) | 471 (16.6) | 142 (12.1) | — | 1339 (12.1) | 5290 (12.2) |
| Relatives, no. (%) | ||||||
| Any relative | 12 374 (100) | 7499 (100) | 2471 (100) | 2233 (100) | 24 577 (100) | 99 542 (100) |
| Parents | 1880 (15.2) | 1557 (20.8) | 345 (14.0) | 408 (18.3) | 4190 (17.0) | 17 100 (17.2) |
| Siblings | 1450 (11.7) | 1237 (16.5) | 284 (11.5) | 345 (15.4) | 3316 (13.5) | 13 635 (13.7) |
| Offspring | 9044 (73.1) | 4705 (62.7) | 1842 (74.5) | 1480 (66.3) | 17 071 (69.5) | 68 807 (69.1) |
| Variable . | MPN patients . | Controls . | ||||
|---|---|---|---|---|---|---|
| PV . | ET . | MF . | MPN NOS . | Any MPN . | ||
| No. (%) of patients | 6217 (100) | 2838 (100) | 1172 (100) | 812 (100) | 11 039 (100) | 43 550 (100) |
| Male, sex, n (%) | 3078 (49.5) | 1214 (42.8) | 644 (55.0) | 401 (49.4) | 5337 (48.4) | 21 152 (48.6) |
| Age at diagnosis, y [mean (range)] | 66 (3-97) | 66 (1-98) | 69 (16-93) | 71 (20-97) | 67 (1-90) | 67 (1-98) |
| Age group at diagnosis, no. (%) | ||||||
| Younger than 40 y | 208 (3.4) | 212 (7.5) | 22 (1.9) | 18 (2.2) | 460 (4.2) | 1840 (4.2) |
| 40-49 y | 443 (7.1) | 253 (8.9) | 57 (4.9) | 41 (5.1) | 794 (7.2) | 3174 (7.3) |
| 50-59 y | 1037 (16.7) | 385 (13.6) | 150 (12.8) | 74 (9.1) | 1646 (14.9) | 6572 (15.0) |
| 60-69 y | 1661 (26.7) | 580 (20.4) | 310 (26.4) | 177 (21.8) | 2728 (24.7) | 10 826 (24.9) |
| 70-79 y | 1968 (31.6) | 865 (30.5) | 431 (36.8) | 269 (33.1) | 3533 (32.0) | 13 834 (31.8) |
| Older than 80 y | 900 (14.5) | 543 (19.1) | 202 (17.2) | 233 (28.7) | 1878 (17.1) | 7304 (16.8) |
| Year of birth, mean (range) | 1917 (1872-1993) | 1926 (1875-1990) | 1919 (1879-1979) | 1927 (1901-1982) | 1920 (1872-1993) | 1921 (1872-1993) |
| Calendar year of diagnosis, no. (%) | ||||||
| 1958-1965 | 590 (9.5) | 48 (1.7) | 1 (0.1) | — | 639 (5.8) | 2556 (5.9) |
| 1966-1975 | 1172 (18.9) | 145 (5.1) | 124 (10.6) | — | 1441 (13.1) | 5747 (13.2) |
| 1976-1985 | 1364 (21.9) | 201 (7.1) | 328 (28.0) | — | 1893 (17.2) | 7443 (17.1) |
| 1986-1995 | 1527 (25.5) | 1542 (54.3) | 412 (35.2) | 159 (19.6) | 3640 (32.9) | 14 250 (32.7) |
| 1996-2005 | 1564 (25.2) | 902 (31.8) | 307 (26.2) | 653 (80.4) | 3426 (31.0) | 13 554 (31.1) |
| Data source, no. (%) | ||||||
| Cancer Registry | 5491 (88.3) | 2367 (83.4) | 1030 (87.9) | 812 (100) | 3998 (87.9) | 38 260 (87.8) |
| Local hospitals | 726 (11.7) | 471 (16.6) | 142 (12.1) | — | 1339 (12.1) | 5290 (12.2) |
| Relatives, no. (%) | ||||||
| Any relative | 12 374 (100) | 7499 (100) | 2471 (100) | 2233 (100) | 24 577 (100) | 99 542 (100) |
| Parents | 1880 (15.2) | 1557 (20.8) | 345 (14.0) | 408 (18.3) | 4190 (17.0) | 17 100 (17.2) |
| Siblings | 1450 (11.7) | 1237 (16.5) | 284 (11.5) | 345 (15.4) | 3316 (13.5) | 13 635 (13.7) |
| Offspring | 9044 (73.1) | 4705 (62.7) | 1842 (74.5) | 1480 (66.3) | 17 071 (69.5) | 68 807 (69.1) |
MPN indicates myeloproliferative neoplasm; PV, polycythemia vera; ET, essential thrombocythemia; MF, myelofibrosis; and NOS, unclassifiable.