Relative risk of MPN among first-degree relatives of MPN patients
| Proband . | Any MPN . | PV . | ET . | MF . | MPN NOS . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patients . | Controls . | RR (95% CI) . | Patients . | Controls . | RR (95% CI) . | Patients . | Controls . | RR (95% CI) . | Patients . | Controls . | RR (95% CI) . | Patients . | Controls . | RR (95% CI) . | |
| Any MPN | 95 | 69 | 5.6 (3.8-8.2) | 53 | 38 | 5.7 (3.5-9.1) | 29 | 16 | 7.4 (3.7-14.8) | 2 | 9 | 0.9 (0.2-4.2) | 11 | 6 | 7.5 (2.7-20.8) |
| PV | 53 | 44 | 4.9 (3.1-7.8) | 37 | 25 | 6.0 (3.3-11.0) | 12 | 9 | 5.4 (2.2-13.2) | 0 | 6 | NA | 4 | 4 | 4.1 (1.0-16.2) |
| ET | 29 | 17 | 6.8 (3.4-13.5) | 12 | 9 | 5.4 (2.2-13.1) | 12 | 6 | 8.0 (2.6-24.5) | 1 | 1 | 4.0 (0.2-61.7) | 4 | 1 | 16.6 (1.9-146.1) |
| MF | 2 | 3 | 2.7 (0.5-16.2) | 0 | 2 | NA | 0 | 1 | NA | 0 | 1 | N.A | 1 | 0 | NA |
| MPN NOS | 11 | 5 | 9.4 (3.2-28.0) | 4 | 2 | 8.4 (1.5-46.4) | 4 | 1 | 17.5 (1.9-16.3) | 1 | 1 | 4.1 (0.2-63.1) | 2 | 1 | 8.9 (0.6-140.1) |
| Proband . | Any MPN . | PV . | ET . | MF . | MPN NOS . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patients . | Controls . | RR (95% CI) . | Patients . | Controls . | RR (95% CI) . | Patients . | Controls . | RR (95% CI) . | Patients . | Controls . | RR (95% CI) . | Patients . | Controls . | RR (95% CI) . | |
| Any MPN | 95 | 69 | 5.6 (3.8-8.2) | 53 | 38 | 5.7 (3.5-9.1) | 29 | 16 | 7.4 (3.7-14.8) | 2 | 9 | 0.9 (0.2-4.2) | 11 | 6 | 7.5 (2.7-20.8) |
| PV | 53 | 44 | 4.9 (3.1-7.8) | 37 | 25 | 6.0 (3.3-11.0) | 12 | 9 | 5.4 (2.2-13.2) | 0 | 6 | NA | 4 | 4 | 4.1 (1.0-16.2) |
| ET | 29 | 17 | 6.8 (3.4-13.5) | 12 | 9 | 5.4 (2.2-13.1) | 12 | 6 | 8.0 (2.6-24.5) | 1 | 1 | 4.0 (0.2-61.7) | 4 | 1 | 16.6 (1.9-146.1) |
| MF | 2 | 3 | 2.7 (0.5-16.2) | 0 | 2 | NA | 0 | 1 | NA | 0 | 1 | N.A | 1 | 0 | NA |
| MPN NOS | 11 | 5 | 9.4 (3.2-28.0) | 4 | 2 | 8.4 (1.5-46.4) | 4 | 1 | 17.5 (1.9-16.3) | 1 | 1 | 4.1 (0.2-63.1) | 2 | 1 | 8.9 (0.6-140.1) |
All estimates were adjusted for sex of first-degree relative.
MPN indicates myeloproliferative neoplasm; PV, polycythemia vera; ET, essential thrombocythemia; MF, myelofibrosis; NOS, unclassifiable; RR, relative risk; CI, confidence interval; and NA, not applicable.