The frequency of DHFR haplotypes in ALL patients with and without event
| Haplotypes . | Event, no. (%) . | Nonevent, no. (%) . | Total, no. (%) . | P* . |
|---|---|---|---|---|
| *1a | 31 (28.7) | 85 (19.2) | 116 (21.1) | .04 |
| *1b | 3 (2.8) | 21 (4.8) | 24 (4.4) | .6 |
| *2 | 1 (0.9) | 4 (0.9) | 5 (0.9) | >.9 |
| *3 | 38 (35.2) | 144 (32.6) | 182 (33.1) | .6 |
| *4 | 4 (3.7) | 54 (12.2) | 58 (10.5) | .005 |
| *5a | 23 (21.3) | 123 (27.8) | 146 (26.5) | .2 |
| *5b | 8 (7.4) | 11 (2.5) | 19 (3.5) | .02 |
| Total† | 108 (100) | 442 (100) | 550 (100) | — |
| Haplotypes . | Event, no. (%) . | Nonevent, no. (%) . | Total, no. (%) . | P* . |
|---|---|---|---|---|
| *1a | 31 (28.7) | 85 (19.2) | 116 (21.1) | .04 |
| *1b | 3 (2.8) | 21 (4.8) | 24 (4.4) | .6 |
| *2 | 1 (0.9) | 4 (0.9) | 5 (0.9) | >.9 |
| *3 | 38 (35.2) | 144 (32.6) | 182 (33.1) | .6 |
| *4 | 4 (3.7) | 54 (12.2) | 58 (10.5) | .005 |
| *5a | 23 (21.3) | 123 (27.8) | 146 (26.5) | .2 |
| *5b | 8 (7.4) | 11 (2.5) | 19 (3.5) | .02 |
| Total† | 108 (100) | 442 (100) | 550 (100) | — |