WHO classification of the mature B-cell, T-cell, and NK-cell neoplasms (2008)
| Mature B-cell neoplasms |
| Chronic lymphocytic leukemia/small lymphocytic lymphoma |
| B-cell prolymphocytic leukemia |
| Splenic marginal zone lymphoma |
| Hairy cell leukemia |
| Splenic lymphoma/leukemia, unclassifiable* |
| Splenic diffuse red pulp small B-cell lymphoma* |
| Hairy cell leukemia-variant* |
| Lymphoplasmacytic lymphoma |
| Waldenström macroglobulinemia |
| Heavy chain diseases |
| Alpha heavy chain disease |
| Gamma heavy chain disease |
| Mu heavy chain disease |
| Plasma cell myeloma |
| Solitary plasmacytoma of bone |
| Extraosseous plasmacytoma |
| Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue |
| (MALT lymphoma) |
| Nodal marginal zone lymphoma |
| Pediatric nodal marginal zone lymphoma* |
| Follicular lymphoma |
| Pediatric follicular lymphoma* |
| Primary cutaneous follicle center lymphoma |
| Mantle cell lymphoma |
| Diffuse large B-cell lymphoma (DLBCL), NOS |
| T-cell/histiocyte rich large B-cell lymphoma |
| Primary DLBCL of the CNS |
| Primary cutaneous DLBCL, leg type |
| EBV+ DLBCL of the elderly* |
| DLBCL associated with chronic inflammation |
| Lymphomatoid granulomatosis |
| Primary mediastinal (thymic) large B-cell lymphoma |
| Intravascular large B-cell lymphoma |
| ALK+ large B-cell lymphoma |
| Plasmablastic lymphoma |
| Large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease |
| Primary effusion lymphoma |
| Burkitt lymphoma |
| B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma |
| B-cell lymphoma, unclassifiable, with features intermediate between diffuse |
| large B-cell lymphoma and classical Hodgkin lymphoma |
| Mature T-cell and NK-cell neoplasms |
| T-cell prolymphocytic leukemia |
| T-cell large granular lymphocytic leukemia |
| Chronic lymphoproliferative disorder of NK cells* |
| Aggressive NK cell leukemia |
| Systemic EBV+ T-cell lymphoproliferative disease of childhood |
| Hydroa vacciniforme-like lymphoma |
| Adult T-cell leukemia/lymphoma |
| Extranodal NK/T-cell lymphoma, nasal type |
| Enteropathy-associated T-cell lymphoma |
| Hepatosplenic T-cell lymphoma |
| Subcutaneous panniculitis-like T-cell lymphoma |
| Mycosis fungoides |
| Sézary syndrome |
| Primary cutaneous CD30+ T-cell lymphoproliferative disorders |
| Lymphomatoid papulosis |
| Primary cutaneous anaplastic large cell lymphoma |
| Primary cutaneous gamma-delta T-cell lymphoma |
| Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma* |
| Primary cutaneous CD4+ small/medium T-cell lymphoma* |
| Peripheral T-cell lymphoma, NOS |
| Angioimmunoblastic T-cell lymphoma |
| Anaplastic large cell lymphoma, ALK+ |
| Anaplastic large cell lymphoma, ALK−* |
| Hodgkin lymphoma |
| Nodular lymphocyte-predominant Hodgkin lymphoma |
| Classical Hodgkin lymphoma |
| Nodular sclerosis classical Hodgkin lymphoma |
| Lymphocyte-rich classical Hodgkin lymphoma |
| Mixed cellularity classical Hodgkin lymphoma |
| Lymphocyte-depleted classical Hodgkin lymphoma |
| Posttransplantation lymphoproliferative disorders (PTLD) |
| Early lesions |
| Plasmacytic hyperplasia |
| Infectious mononucleosis-like PTLD |
| Polymorphic PTLD |
| Monomorphic PTLD (B- and T/NK-cell types)† |
| Classical Hodgkin lymphoma type PTLD† |
| Mature B-cell neoplasms |
| Chronic lymphocytic leukemia/small lymphocytic lymphoma |
| B-cell prolymphocytic leukemia |
| Splenic marginal zone lymphoma |
| Hairy cell leukemia |
| Splenic lymphoma/leukemia, unclassifiable* |
| Splenic diffuse red pulp small B-cell lymphoma* |
| Hairy cell leukemia-variant* |
| Lymphoplasmacytic lymphoma |
| Waldenström macroglobulinemia |
| Heavy chain diseases |
| Alpha heavy chain disease |
| Gamma heavy chain disease |
| Mu heavy chain disease |
| Plasma cell myeloma |
| Solitary plasmacytoma of bone |
| Extraosseous plasmacytoma |
| Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue |
| (MALT lymphoma) |
| Nodal marginal zone lymphoma |
| Pediatric nodal marginal zone lymphoma* |
| Follicular lymphoma |
| Pediatric follicular lymphoma* |
| Primary cutaneous follicle center lymphoma |
| Mantle cell lymphoma |
| Diffuse large B-cell lymphoma (DLBCL), NOS |
| T-cell/histiocyte rich large B-cell lymphoma |
| Primary DLBCL of the CNS |
| Primary cutaneous DLBCL, leg type |
| EBV+ DLBCL of the elderly* |
| DLBCL associated with chronic inflammation |
| Lymphomatoid granulomatosis |
| Primary mediastinal (thymic) large B-cell lymphoma |
| Intravascular large B-cell lymphoma |
| ALK+ large B-cell lymphoma |
| Plasmablastic lymphoma |
| Large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease |
| Primary effusion lymphoma |
| Burkitt lymphoma |
| B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma |
| B-cell lymphoma, unclassifiable, with features intermediate between diffuse |
| large B-cell lymphoma and classical Hodgkin lymphoma |
| Mature T-cell and NK-cell neoplasms |
| T-cell prolymphocytic leukemia |
| T-cell large granular lymphocytic leukemia |
| Chronic lymphoproliferative disorder of NK cells* |
| Aggressive NK cell leukemia |
| Systemic EBV+ T-cell lymphoproliferative disease of childhood |
| Hydroa vacciniforme-like lymphoma |
| Adult T-cell leukemia/lymphoma |
| Extranodal NK/T-cell lymphoma, nasal type |
| Enteropathy-associated T-cell lymphoma |
| Hepatosplenic T-cell lymphoma |
| Subcutaneous panniculitis-like T-cell lymphoma |
| Mycosis fungoides |
| Sézary syndrome |
| Primary cutaneous CD30+ T-cell lymphoproliferative disorders |
| Lymphomatoid papulosis |
| Primary cutaneous anaplastic large cell lymphoma |
| Primary cutaneous gamma-delta T-cell lymphoma |
| Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma* |
| Primary cutaneous CD4+ small/medium T-cell lymphoma* |
| Peripheral T-cell lymphoma, NOS |
| Angioimmunoblastic T-cell lymphoma |
| Anaplastic large cell lymphoma, ALK+ |
| Anaplastic large cell lymphoma, ALK−* |
| Hodgkin lymphoma |
| Nodular lymphocyte-predominant Hodgkin lymphoma |
| Classical Hodgkin lymphoma |
| Nodular sclerosis classical Hodgkin lymphoma |
| Lymphocyte-rich classical Hodgkin lymphoma |
| Mixed cellularity classical Hodgkin lymphoma |
| Lymphocyte-depleted classical Hodgkin lymphoma |
| Posttransplantation lymphoproliferative disorders (PTLD) |
| Early lesions |
| Plasmacytic hyperplasia |
| Infectious mononucleosis-like PTLD |
| Polymorphic PTLD |
| Monomorphic PTLD (B- and T/NK-cell types)† |
| Classical Hodgkin lymphoma type PTLD† |