Correlation between the Ik isoforms (DNA-binding isoform [A], Ik1-Ik2; coexpression of both DNA-binding and non–DNA-binding isoforms [B]; dominant non–DNA-binding isoform Ik6 [C]), the status of disease and the BCR-ABL transcript levels, expressed as a ratio (BCR-ABL/ABL) and monitored by RQ-PCR
| Disease phase . | A . | B . | C . | |||
|---|---|---|---|---|---|---|
| No. (%) of patients . | Ratio, % . | No. (%) of patients . | Ratio, % . | No. (%) of patients . | Ratio, % . | |
| Diagnosis | 5 (12) | 33.41 | 22 (54) | 51.40 | 14 (34) | 69.01 |
| Remission | 27 (100) | 0.001 | ||||
| Relapse | 2 (9) | 52.66 | 5 (24) | 23.33 | 14 (67) | 58.75 |
| Disease phase . | A . | B . | C . | |||
|---|---|---|---|---|---|---|
| No. (%) of patients . | Ratio, % . | No. (%) of patients . | Ratio, % . | No. (%) of patients . | Ratio, % . | |
| Diagnosis | 5 (12) | 33.41 | 22 (54) | 51.40 | 14 (34) | 69.01 |
| Remission | 27 (100) | 0.001 | ||||
| Relapse | 2 (9) | 52.66 | 5 (24) | 23.33 | 14 (67) | 58.75 |
Ik isoforms are expressed as n; ratios are expressed as BCR-ABL/ABL (%; median).