Odds ratio (OR) and 95% confidence interval for mtDNA copy number and non-Hodgkin lymphoma
| Diagnosis . | mtDNA copy number . | ||||
|---|---|---|---|---|---|
| Continuous (/15 increment) . | Tertile 1 (60.7-102.6) . | Tertile 2 (102.7-126.5) . | Tertile 3 (126.6-295.9) . | Ptrend . | |
| NHL | |||||
| n | 104/104 | 23/33 | 36/36 | 45/35 | |
| Unadjusted OR (95% CI) | 1.2 (1.1-1.5) | 1.0 (ref) | 1.4 (0.7-2.8) | 2.4 (1.0-5.5) | .046 |
| Multivariable OR (95% CI) | 1.3 (1.1-1.6) | 1.0 (ref) | 1.7 (0.8-3.5) | 3.9 (1.4-11.0) | .010 |
| Diffuse large B-cell NHL | |||||
| N | 24/24 | 6/7 | 10 /8 | 8/9 | |
| Unadjusted OR (95% CI) | 1.1 (0.8-1.4) | 1.0 (ref) | 1.7 (0.3-9.0) | 1.0 (0.2-5.9) | .88 |
| Multivariable OR (95% CI) | 1.4 (0.8-2.4) | 1.0 (ref) | 3.7 (0.4-37.0) | 0.7 (0.1-8.2) | .82 |
| CLL/SLL | |||||
| n | 34/34 | 3/11 | 12/14 | 19/9 | |
| Unadjusted OR (95% CI) | 1.5 (1.1-2.2) | 1.0 (ref) | 3.2 (0.7-15.7) | 14.1 (1.9-103.2) | .009 |
| Multivariable OR (95% CI) | 1.7 (1.1-2.7) | 1.0 (ref) | 1.2 (0.1-10.6) | 27.7 (1.4-563.6) | .020 |
| NHL excluding CLL/SLL | |||||
| n | 70/70 | 20/22 | 24/22 | 26/26 | |
| Unadjusted OR (95% CI) | 1.1 (1.0-1.4) | 1.0 (ref) | 1.2 (0.5-2.6) | 1.1 (0.4-3.1) | .84 |
| Multivariable OR (95% CI) | 1.2 (1.0-1.5) | 1.0 (ref) | 1.4 (0.6-3.5) | 2.0 (0.5-7.0) | .29 |
| Diagnosis . | mtDNA copy number . | ||||
|---|---|---|---|---|---|
| Continuous (/15 increment) . | Tertile 1 (60.7-102.6) . | Tertile 2 (102.7-126.5) . | Tertile 3 (126.6-295.9) . | Ptrend . | |
| NHL | |||||
| n | 104/104 | 23/33 | 36/36 | 45/35 | |
| Unadjusted OR (95% CI) | 1.2 (1.1-1.5) | 1.0 (ref) | 1.4 (0.7-2.8) | 2.4 (1.0-5.5) | .046 |
| Multivariable OR (95% CI) | 1.3 (1.1-1.6) | 1.0 (ref) | 1.7 (0.8-3.5) | 3.9 (1.4-11.0) | .010 |
| Diffuse large B-cell NHL | |||||
| N | 24/24 | 6/7 | 10 /8 | 8/9 | |
| Unadjusted OR (95% CI) | 1.1 (0.8-1.4) | 1.0 (ref) | 1.7 (0.3-9.0) | 1.0 (0.2-5.9) | .88 |
| Multivariable OR (95% CI) | 1.4 (0.8-2.4) | 1.0 (ref) | 3.7 (0.4-37.0) | 0.7 (0.1-8.2) | .82 |
| CLL/SLL | |||||
| n | 34/34 | 3/11 | 12/14 | 19/9 | |
| Unadjusted OR (95% CI) | 1.5 (1.1-2.2) | 1.0 (ref) | 3.2 (0.7-15.7) | 14.1 (1.9-103.2) | .009 |
| Multivariable OR (95% CI) | 1.7 (1.1-2.7) | 1.0 (ref) | 1.2 (0.1-10.6) | 27.7 (1.4-563.6) | .020 |
| NHL excluding CLL/SLL | |||||
| n | 70/70 | 20/22 | 24/22 | 26/26 | |
| Unadjusted OR (95% CI) | 1.1 (1.0-1.4) | 1.0 (ref) | 1.2 (0.5-2.6) | 1.1 (0.4-3.1) | .84 |
| Multivariable OR (95% CI) | 1.2 (1.0-1.5) | 1.0 (ref) | 1.4 (0.6-3.5) | 2.0 (0.5-7.0) | .29 |
Multivariable model adjusted for pack-years, height, systolic blood pressure, and leisure-time physical activity (5 categories, combining intensity and frequency). NHL indicates non-Hodgkin lymphoma; CLL/SLL, chronic lymphocytic leukemia/small lymphocytic leukemia.