Pathway classification analysis of VEGF-A–induced genes in LECs
| Molecular function . | 1 h . | 4 h . | 8 h . | 24 h . | Biological process . | 1 h . | 4 h . | 8 h . | 24 h . |
|---|---|---|---|---|---|---|---|---|---|
| Cytokine receptor | ++ | ++ | ++ | ++ | Cell proliferation and differentiation | +++ | + | + | + |
| Phosphorylase | ++ | ++ | ++ | ++ | Developmental processes | +++ | + | + | + |
| Growth factor | + | +++ | + | + | Nucleoside, nucleotide, and nucleic acid metabolism | +++ | + | + | + |
| Kinase modulator | + | + | + | + | Intracellular signaling cascade | ++ | ++ | + | + |
| Kinase inhibitor | + | + | ++ | − | MAPKKK cascade | +++ | ++ | +++ | − |
| Phosphatase | ++ | + | +++ | − | Immunity and defense | ++ | ++ | ++ | − |
| Basic helix-loop-helix transcription factor | + | + | + | − | Receptor protein tyrosine kinase signaling pathway | + | + | ++ | − |
| Signaling molecule | +++ | +++ | + | − | JNK cascade | + | + | + | − |
| Carbohydrate phosphatase | ++ | +++ | +++ | − | Signal transduction | +++ | +++ | + | − |
| Kinase | + | + | − | +++ | Protein phosphorylation | +++ | + | − | +++ |
| Select regulatory molecule | + | − | + | + | Ligand-mediated signaling | +++ | +++ | − | − |
| Protein phosphatase | + | − | ++ | − | Cell communication | +++ | ++ | − | − |
| Transcription factor | +++ | − | − | − | Cell cycle | + | − | + | +++ |
| Metalloprotease | + | − | − | − | Cell-cycle control | +++ | − | + | +++ |
| Defense/immunity protein | − | + | + | − | Protein modification | + | − | − | ++ |
| RNA-binding protein | − | + | + | − | Inhibition of apoptosis | ++ | − | − | + |
| Replication origin binding protein | − | − | + | ++ | Cell-surface receptor–mediated signal transduction | ++ | − | − | − |
| Transaminase | − | − | ++ | + | mRNA transcription | +++ | − | − | − |
| Transferase | − | − | + | − | Cell adhesion–mediated signaling | + | − | − | − |
| Microtubule binding motor protein | − | − | − | +++ | Neurogenesis | + | − | − | − |
| Microtubule family cytoskeletal protein | − | − | − | +++ | Complement-mediated immunity | − | + | + | + |
| Cytoskeletal protein | − | − | − | +++ | Angiogenesis | − | + | + | + |
| Protein kinase | − | − | − | ++ | Amino acid biosynthesis | − | − | + | ++ |
| Actin binding motor protein | − | − | − | + | Mitosis | − | − | − | +++ |
| DNA topoisomerase | − | − | − | + | Chromosome segregation | − | − | − | +++ |
| DNA strand-pairing protein | − | − | − | + | Cytokinesis | − | − | − | +++ |
| DNA helicase | − | − | − | + | DNA replication | − | − | − | ++ |
| Molecular function . | 1 h . | 4 h . | 8 h . | 24 h . | Biological process . | 1 h . | 4 h . | 8 h . | 24 h . |
|---|---|---|---|---|---|---|---|---|---|
| Cytokine receptor | ++ | ++ | ++ | ++ | Cell proliferation and differentiation | +++ | + | + | + |
| Phosphorylase | ++ | ++ | ++ | ++ | Developmental processes | +++ | + | + | + |
| Growth factor | + | +++ | + | + | Nucleoside, nucleotide, and nucleic acid metabolism | +++ | + | + | + |
| Kinase modulator | + | + | + | + | Intracellular signaling cascade | ++ | ++ | + | + |
| Kinase inhibitor | + | + | ++ | − | MAPKKK cascade | +++ | ++ | +++ | − |
| Phosphatase | ++ | + | +++ | − | Immunity and defense | ++ | ++ | ++ | − |
| Basic helix-loop-helix transcription factor | + | + | + | − | Receptor protein tyrosine kinase signaling pathway | + | + | ++ | − |
| Signaling molecule | +++ | +++ | + | − | JNK cascade | + | + | + | − |
| Carbohydrate phosphatase | ++ | +++ | +++ | − | Signal transduction | +++ | +++ | + | − |
| Kinase | + | + | − | +++ | Protein phosphorylation | +++ | + | − | +++ |
| Select regulatory molecule | + | − | + | + | Ligand-mediated signaling | +++ | +++ | − | − |
| Protein phosphatase | + | − | ++ | − | Cell communication | +++ | ++ | − | − |
| Transcription factor | +++ | − | − | − | Cell cycle | + | − | + | +++ |
| Metalloprotease | + | − | − | − | Cell-cycle control | +++ | − | + | +++ |
| Defense/immunity protein | − | + | + | − | Protein modification | + | − | − | ++ |
| RNA-binding protein | − | + | + | − | Inhibition of apoptosis | ++ | − | − | + |
| Replication origin binding protein | − | − | + | ++ | Cell-surface receptor–mediated signal transduction | ++ | − | − | − |
| Transaminase | − | − | ++ | + | mRNA transcription | +++ | − | − | − |
| Transferase | − | − | + | − | Cell adhesion–mediated signaling | + | − | − | − |
| Microtubule binding motor protein | − | − | − | +++ | Neurogenesis | + | − | − | − |
| Microtubule family cytoskeletal protein | − | − | − | +++ | Complement-mediated immunity | − | + | + | + |
| Cytoskeletal protein | − | − | − | +++ | Angiogenesis | − | + | + | + |
| Protein kinase | − | − | − | ++ | Amino acid biosynthesis | − | − | + | ++ |
| Actin binding motor protein | − | − | − | + | Mitosis | − | − | − | +++ |
| DNA topoisomerase | − | − | − | + | Chromosome segregation | − | − | − | +++ |
| DNA strand-pairing protein | − | − | − | + | Cytokinesis | − | − | − | +++ |
| DNA helicase | − | − | − | + | DNA replication | − | − | − | ++ |
+ indicates P < .05; ++, P < .01; +++, P < .001; and −, not statistically significant.