Table 1 Signaling of FLT3 mutant... | American Society of Hematology

Table 1

Signaling of FLT3 mutant proteins and effect of ER targeting

	Autophosphorylation		Activation				Proliferation	Colony formation	MPD formation
	130 kDa	150 kDa	STAT5	STAT3	ERK1/2	AKT	Proliferation	Colony formation	MPD formation
FLT3 D835Y	+	+++	−	−	(+)	+	+	−	−
FLT3 D835Y R3	+	−	−	++	−	−	−	−	−
FLT3 ITD	+	+++	+++	+	++	++	++	+++	++
FLT3 ITD R3	++	−	++	++	(+)	+	++	++	+

	Autophosphorylation		Activation				Proliferation	Colony formation	MPD formation
	130 kDa	150 kDa	STAT5	STAT3	ERK1/2	AKT	Proliferation	Colony formation	MPD formation
FLT3 D835Y	+	+++	−	−	(+)	+	+	−	−
FLT3 D835Y R3	+	−	−	++	−	−	−	−	−
FLT3 ITD	+	+++	+++	+	++	++	++	+++	++
FLT3 ITD R3	++	−	++	++	(+)	+	++	++	+