Percentages of annexin V+ staining erythroid progenitors in the bone marrow and spleen of humanized CA versus control mice
| Tissue . | Cells (region) . | Annexin V+ (%) . | P . | |
|---|---|---|---|---|
| Control mice . | CA mice . | |||
| Bone marrow | Early erythroblasts (II) | 13.9 (± 3.3) | 33.7 (± 3.5) | .0059 |
| Late erythroblasts (III) | 1.8 (± 0.3) | 50.0 (± 2.5) | < .0001 | |
| Spleen | Early erythroblasts (II) | 13.6 (± 4.5) | 20.9 (± 4.8) | .3099 |
| Late erythroblasts (III) | 0.9 (± 0.3) | 53.2 (± 1.6) | < .0001 | |
| Tissue . | Cells (region) . | Annexin V+ (%) . | P . | |
|---|---|---|---|---|
| Control mice . | CA mice . | |||
| Bone marrow | Early erythroblasts (II) | 13.9 (± 3.3) | 33.7 (± 3.5) | .0059 |
| Late erythroblasts (III) | 1.8 (± 0.3) | 50.0 (± 2.5) | < .0001 | |
| Spleen | Early erythroblasts (II) | 13.6 (± 4.5) | 20.9 (± 4.8) | .3099 |
| Late erythroblasts (III) | 0.9 (± 0.3) | 53.2 (± 1.6) | < .0001 | |
Statistical significances were determined for the CA mice compared with control mice. Annexin V+ erythroid populations of humanized HbA mice (α2α1/α2α1 γβA/γβA) and C57BL/6J control mice do not differ significantly (data not shown). Percentages are mean (± SEM). n = 4 in each group. P values were calculated by 2-tailed unpaired Student t test.