Table 1

Probe sets uniquely up-regulated in deletional tolerance

Affymetrix probe IDGene symbolGene nameLog fold changeAssociation with T-cell tolerance?
1419083_at Tnfsf11 Tumor necrosis factor (ligand) superfamily, member 11 6.49 Yes19  
1455265_a_at Rgs16 Regulator of G-protein signaling 16 4.8 No 
1428393_at Nrn1 Neuritin 1 4.43 No 
1456956_at Ikzf2 IKAROS family zinc finger 2 4.04 Yes47  
1435292_at Tbc1d4 TBC1 domain family, member 4 3.96 No 
1455034_at — — 3.46 No 
1423091_a_at Gpm6b Glycoprotein m6b 3.08 No 
1426542_at Endod1 Endonuclease domain containing 1 2.93 No 
1425062_at Fcrl1 Fc receptor-like 1 2.71 No 
1449893_a_at Lrig1 Leucine-rich repeats and immunoglobulin-like domains 1 2.66 Putative 
1434210_s_at Lrig1 Leucine-rich repeats and immunoglobulin-like domains 1 2.59 Putative 
1415973_at Marcks Myristoylated alanine rich protein kinase C substrate 2.46 No 
1438796_at Nr4a3 Nuclear receptor subfamily 4, group A, member 3 2.38 Yes35,61  
1420353_at Lta Lymphotoxin A 2.21 No 
1455418_at — — 2.14 No 
1456028_x_at Marcks Myristoylated alanine-rich protein kinase C substrate 1.81 No 
1452344_at Synj2 Synaptojanin 2 1.79 No 
1416505_at Nr4a1 Nuclear receptor subfamily 4, group A, member 1 1.74 Yes61  
1449010_at Hspa4l Heat shock protein 4-like 1.73 No 
1460121_at Ptprs Protein tyrosine phosphatase, receptor type, S 1.65 Yes46  
1427683_at Egr2 Early growth response 2 1.63 Yes35  
1418758_a_at Pscd3 Pleckstrin homology, Sec7 and coiled-coil domains 3 1.56 Yes48  
1438331_at Ypel2 Yippee-like 2 (Drosophila) 1.39 No 
1427682_a_at Egr2 Early growth response 2 1.32 Yes 
1422054_a_at Skil SKI-like 1.26 No 
1417930_at Nab2 Ngfi-A binding protein 2 1.17 No 
1417695_a_at Soat1 Sterol O-acyltransferase 1 1.17 No 
1452583_s_at Galm Galactose mutarotase 1.15 No 
1445612_at Tox Thymocyte selection-associated HMG box gene 1.11 Putative 
1437918_at 4930539E08Rik RIKEN cDNA 4930539E08 gene 1.08 No 
1424778_at Reep3 Receptor accessory protein 3 1.05 No 
1438338_at Mdh1 Malate dehydrogenase 1, NAD (soluble) 1.04 No 
1429472_at 4921525O09Rik RIKEN cDNA 4921525O09 gene 1.01 No 
1422438_at Ephx1 Epoxide hydrolase 1, microsomal 0.96 No 
1455854_a_at Ssh1 Slingshot homolog 1 (Drosophila) 0.96 No 
1449037_at Crem cAMP-responsive element modulator 0.95 Yes41,45  
1449381_a_at Pacsin1 Protein kinase C and casein kinase substrate in neurons 1 0.95 No 
1424460_s_at Lpcat1 Acyltransferase-like 2 0.87 No 
1416844_at Prmt2 Protein arginine N-methyltransferase 2 0.84 No 
1439703_at Cd200r1 CD200 receptor 1 0.8 No 
1434384_at Nrip1 Nuclear receptor interacting protein 1 0.76 No 
1452169_a_at Dgkz Diacylglycerol kinase zeta 0.76 Yes38,39  
1426476_at Rasa1 RAS p21 protein activator 1 0.74 Yes40  
1430357_at H3f3b H3 histone, family 3B 0.73 No 
1434273_at A830073O21Rik RIKEN cDNA A830073O21 gene 0.66 No 
Affymetrix probe IDGene symbolGene nameLog fold changeAssociation with T-cell tolerance?
1419083_at Tnfsf11 Tumor necrosis factor (ligand) superfamily, member 11 6.49 Yes19  
1455265_a_at Rgs16 Regulator of G-protein signaling 16 4.8 No 
1428393_at Nrn1 Neuritin 1 4.43 No 
1456956_at Ikzf2 IKAROS family zinc finger 2 4.04 Yes47  
1435292_at Tbc1d4 TBC1 domain family, member 4 3.96 No 
1455034_at — — 3.46 No 
1423091_a_at Gpm6b Glycoprotein m6b 3.08 No 
1426542_at Endod1 Endonuclease domain containing 1 2.93 No 
1425062_at Fcrl1 Fc receptor-like 1 2.71 No 
1449893_a_at Lrig1 Leucine-rich repeats and immunoglobulin-like domains 1 2.66 Putative 
1434210_s_at Lrig1 Leucine-rich repeats and immunoglobulin-like domains 1 2.59 Putative 
1415973_at Marcks Myristoylated alanine rich protein kinase C substrate 2.46 No 
1438796_at Nr4a3 Nuclear receptor subfamily 4, group A, member 3 2.38 Yes35,61  
1420353_at Lta Lymphotoxin A 2.21 No 
1455418_at — — 2.14 No 
1456028_x_at Marcks Myristoylated alanine-rich protein kinase C substrate 1.81 No 
1452344_at Synj2 Synaptojanin 2 1.79 No 
1416505_at Nr4a1 Nuclear receptor subfamily 4, group A, member 1 1.74 Yes61  
1449010_at Hspa4l Heat shock protein 4-like 1.73 No 
1460121_at Ptprs Protein tyrosine phosphatase, receptor type, S 1.65 Yes46  
1427683_at Egr2 Early growth response 2 1.63 Yes35  
1418758_a_at Pscd3 Pleckstrin homology, Sec7 and coiled-coil domains 3 1.56 Yes48  
1438331_at Ypel2 Yippee-like 2 (Drosophila) 1.39 No 
1427682_a_at Egr2 Early growth response 2 1.32 Yes 
1422054_a_at Skil SKI-like 1.26 No 
1417930_at Nab2 Ngfi-A binding protein 2 1.17 No 
1417695_a_at Soat1 Sterol O-acyltransferase 1 1.17 No 
1452583_s_at Galm Galactose mutarotase 1.15 No 
1445612_at Tox Thymocyte selection-associated HMG box gene 1.11 Putative 
1437918_at 4930539E08Rik RIKEN cDNA 4930539E08 gene 1.08 No 
1424778_at Reep3 Receptor accessory protein 3 1.05 No 
1438338_at Mdh1 Malate dehydrogenase 1, NAD (soluble) 1.04 No 
1429472_at 4921525O09Rik RIKEN cDNA 4921525O09 gene 1.01 No 
1422438_at Ephx1 Epoxide hydrolase 1, microsomal 0.96 No 
1455854_a_at Ssh1 Slingshot homolog 1 (Drosophila) 0.96 No 
1449037_at Crem cAMP-responsive element modulator 0.95 Yes41,45  
1449381_a_at Pacsin1 Protein kinase C and casein kinase substrate in neurons 1 0.95 No 
1424460_s_at Lpcat1 Acyltransferase-like 2 0.87 No 
1416844_at Prmt2 Protein arginine N-methyltransferase 2 0.84 No 
1439703_at Cd200r1 CD200 receptor 1 0.8 No 
1434384_at Nrip1 Nuclear receptor interacting protein 1 0.76 No 
1452169_a_at Dgkz Diacylglycerol kinase zeta 0.76 Yes38,39  
1426476_at Rasa1 RAS p21 protein activator 1 0.74 Yes40  
1430357_at H3f3b H3 histone, family 3B 0.73 No 
1434273_at A830073O21Rik RIKEN cDNA A830073O21 gene 0.66 No 

Log fold change represents log (base 2) fold change. — indicates probe set has no gene annotation.

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