Table 2

Summary of the additive regression models (stepwise method): predictor contribution to therapeutic dose of acenocoumarol and INR value at third day

R2Pβ coefficient (P)
Acenocoumarol dose    
    VKORC1 0.12 .001 −0.349 (.001) 
    VKORC1 plus CYP4F2 0.19 < .001 −0.334 (.001); 0.229 (.018) 
INR at day 3    
    VKORC1 0.08 .007 0.286 (.007) 
    VKORC1 plus CYP4F2 0.14 .001 0.271 (.007); −0.283 (.005) 
R2Pβ coefficient (P)
Acenocoumarol dose    
    VKORC1 0.12 .001 −0.349 (.001) 
    VKORC1 plus CYP4F2 0.19 < .001 −0.334 (.001); 0.229 (.018) 
INR at day 3    
    VKORC1 0.08 .007 0.286 (.007) 
    VKORC1 plus CYP4F2 0.14 .001 0.271 (.007); −0.283 (.005) 

INR indicates international normalized ratio.

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