Patient characteristics at diagnosis
| Characteristic . | Value . |
|---|---|
| Male sex, n (%) | 150 (56) |
| Presenting WBC × 109/L (2 unknown) | |
| < 30, n (%) | 140 (52) |
| ≥ 30, n (%) | 125 (47) |
| Median (range) | 26.8 (1.5-438) |
| Immunophenotype (8 unknown), n (%) | |
| B lineage (8 null) | 247 (95) |
| T cell | 1 (< 1) |
| Mature B | 2 (1) |
| Aberrant myeloid markers | 6 (2) |
| Other | 3 (1) |
| Age, y | |
| < 20, n (%) | 12 (4) |
| 20-29, n (%) | 53 (20) |
| 30-39, n (%) | 68 (25) |
| 40-49, n (%) | 88 (33) |
| ≥ 50, n (%) | 46 (17) |
| Median (range) | 40 (15-60) |
| CNS disease (82 unknown), n (%) | 14 (8) |
| Ph/BCR-ABL detection method,* n (%) | |
| Cytogenetics | 209 (78) |
| FISH | 76 (28) |
| RT-PCR | 218 (82) |
| BCR breakpoint (124 unknown), n (%) | |
| Major | 42 (29) |
| Minor | 100 (70) |
| Both | 1 (< 1) |
| Additional cytogenetic abnormalities (46 unknown), n (%) | |
| Extra Ph chromosome [+der(22)] | 49 (22) |
| −7 | 31 (14) |
| +8 | 24 (11) |
| del(9p) | 24 (11) |
| High hyperdiploidy (HeH) | 28 (13) |
| t(4;11), t(1;19), t(8;14), or low hypodiploidy/near tridiploidy | 0 |
| Characteristic . | Value . |
|---|---|
| Male sex, n (%) | 150 (56) |
| Presenting WBC × 109/L (2 unknown) | |
| < 30, n (%) | 140 (52) |
| ≥ 30, n (%) | 125 (47) |
| Median (range) | 26.8 (1.5-438) |
| Immunophenotype (8 unknown), n (%) | |
| B lineage (8 null) | 247 (95) |
| T cell | 1 (< 1) |
| Mature B | 2 (1) |
| Aberrant myeloid markers | 6 (2) |
| Other | 3 (1) |
| Age, y | |
| < 20, n (%) | 12 (4) |
| 20-29, n (%) | 53 (20) |
| 30-39, n (%) | 68 (25) |
| 40-49, n (%) | 88 (33) |
| ≥ 50, n (%) | 46 (17) |
| Median (range) | 40 (15-60) |
| CNS disease (82 unknown), n (%) | 14 (8) |
| Ph/BCR-ABL detection method,* n (%) | |
| Cytogenetics | 209 (78) |
| FISH | 76 (28) |
| RT-PCR | 218 (82) |
| BCR breakpoint (124 unknown), n (%) | |
| Major | 42 (29) |
| Minor | 100 (70) |
| Both | 1 (< 1) |
| Additional cytogenetic abnormalities (46 unknown), n (%) | |
| Extra Ph chromosome [+der(22)] | 49 (22) |
| −7 | 31 (14) |
| +8 | 24 (11) |
| del(9p) | 24 (11) |
| High hyperdiploidy (HeH) | 28 (13) |
| t(4;11), t(1;19), t(8;14), or low hypodiploidy/near tridiploidy | 0 |
N = 267 patients.
One hundred fifteen cases were positive by cytogenetics and RT-PCR, 47 by RT-PCR alone, 45 by all 3 methods, 29 by cytogenetics alone, 17 by cytogenetics and FISH, 12 by RT-PCR and FISH, and 2 by FISH alone.