Characteristics of complete responders
| Characteristic . | Clofarabine, ratio (%) . | Clofarabine plus LD cytarabine, ratio (%) . | Total, ratio. (%) . | P . |
|---|---|---|---|---|
| Overall number of patients | 5/16 (31) | 34/54 (63) | 39/70 (56) | .025 |
| Karyotype | ||||
| Diploid | 2/6 (33) | 21/27 (78) | 23/33 (70) | .053 |
| Abnormal | 3/8 (38) | 13/27 (48) | 16/35 (46) | .07 |
| −5/−7 | 1/2 (50) | 6/14 (43) | 7/16 (44) | |
| +8 | 0/1 | 2/4 (50) | 2/5 (40) | |
| del(11)(q23) | 1/1 (100) | 1/1 (100) | ||
| Not available/IM | 0/2 | 0/2 | ||
| Flt3 status | ||||
| No abnormality | 5/11 (45) | 31/44 (70) | 36/55 (65) | .161 |
| Abnormal | 0/2 | 2/6 (33) | 2/8 (25) | |
| ITD | 0/2 | 1/5 (20)* | 1/7 (14) | |
| D835 | 2/3 (67)* | 2/3 (67) | ||
| Secondary AML | ||||
| Yes | 2/7 (29) | 15/28 (54) | 17/35 (49) | .402 |
| Yes with diploid karyotype | 0/1 | 8/12 (67) | 8/13 (62) | |
| No | 3/9 (33) | 19/26 (73) | 22/35 (63) | .051 |
| No with diploid karyotype | 1/4 (25) | 11/14 (79) | 12/18 (67) | .083 |
| Age, y | ||||
| 60 to 64 | 1/1 (100) | 7/9 (78) | 8/10 (80) | |
| 65 to 69 | 2/4 (50) | 13/16 (81) | 15/20 (75) | .249 |
| Older than 70 | 2/11 (18) | 14/29 (48) | 16/40 (40) | .148 |
| Characteristic . | Clofarabine, ratio (%) . | Clofarabine plus LD cytarabine, ratio (%) . | Total, ratio. (%) . | P . |
|---|---|---|---|---|
| Overall number of patients | 5/16 (31) | 34/54 (63) | 39/70 (56) | .025 |
| Karyotype | ||||
| Diploid | 2/6 (33) | 21/27 (78) | 23/33 (70) | .053 |
| Abnormal | 3/8 (38) | 13/27 (48) | 16/35 (46) | .07 |
| −5/−7 | 1/2 (50) | 6/14 (43) | 7/16 (44) | |
| +8 | 0/1 | 2/4 (50) | 2/5 (40) | |
| del(11)(q23) | 1/1 (100) | 1/1 (100) | ||
| Not available/IM | 0/2 | 0/2 | ||
| Flt3 status | ||||
| No abnormality | 5/11 (45) | 31/44 (70) | 36/55 (65) | .161 |
| Abnormal | 0/2 | 2/6 (33) | 2/8 (25) | |
| ITD | 0/2 | 1/5 (20)* | 1/7 (14) | |
| D835 | 2/3 (67)* | 2/3 (67) | ||
| Secondary AML | ||||
| Yes | 2/7 (29) | 15/28 (54) | 17/35 (49) | .402 |
| Yes with diploid karyotype | 0/1 | 8/12 (67) | 8/13 (62) | |
| No | 3/9 (33) | 19/26 (73) | 22/35 (63) | .051 |
| No with diploid karyotype | 1/4 (25) | 11/14 (79) | 12/18 (67) | .083 |
| Age, y | ||||
| 60 to 64 | 1/1 (100) | 7/9 (78) | 8/10 (80) | |
| 65 to 69 | 2/4 (50) | 13/16 (81) | 15/20 (75) | .249 |
| Older than 70 | 2/11 (18) | 14/29 (48) | 16/40 (40) | .148 |
Ratios are complete responders per number in group or subgroup.
LD indicates low-dose; IM, insufficient metaphases; ITD, internal tandem duplication; and D835, amino acid mutation at codon aspartate 835.
Two patients with both ITD and D835.