Demographic data for 248 patients treated with high-dose methotrexate and with methotrexate polyglutamate (MTXPG) accumulation data available
| Variable . | n . | Average MTXPG accumulation, pmol/109 cells . | P* . |
|---|---|---|---|
| Age, y | |||
| < 1 | 2 | 2145 | .689 |
| 1-10 | 193 | 3677 | |
| > 10 | 53 | 3688 | |
| Sex | |||
| Female | 110 | 3307 | .633 |
| Male | 138 | 3954 | |
| Race | |||
| Black | 49 | 3166 | .239 |
| White | 199 | 3790 | |
| ALL subtype | |||
| B-hyperdiploid | 61 | 7028 | < 10−6 |
| B-other | 87 | 3727 | |
| TEL-AML1 | 58 | 1960 | |
| T-lineage | 33 | 1076 | |
| E2A-PBX1 | 9 | 804 | |
| Variable . | n . | Average MTXPG accumulation, pmol/109 cells . | P* . |
|---|---|---|---|
| Age, y | |||
| < 1 | 2 | 2145 | .689 |
| 1-10 | 193 | 3677 | |
| > 10 | 53 | 3688 | |
| Sex | |||
| Female | 110 | 3307 | .633 |
| Male | 138 | 3954 | |
| Race | |||
| Black | 49 | 3166 | .239 |
| White | 199 | 3790 | |
| ALL subtype | |||
| B-hyperdiploid | 61 | 7028 | < 10−6 |
| B-other | 87 | 3727 | |
| TEL-AML1 | 58 | 1960 | |
| T-lineage | 33 | 1076 | |
| E2A-PBX1 | 9 | 804 | |
A total of 145, 82, and 144 of these 248 patients had leukemia cell gene expression data, 600 000 SNP chip data, and inherited 600 000 SNP chip data available, respectively.
P values represent the association between the variable and MTXPG accumulation in these patients.