Table 1 IC 50 of DAC, AZA, and Ara-C in... | American Society of Hematology

Table 1

IC₅₀ of DAC, AZA, and Ara-C in human cancer cell lines

Cell line	Tissue	IC₅₀, nM			LINE methylation density %
Cell line	Tissue	DAC	AZA	Ara-C	LINE methylation density %
TF-1	Leukemia	10 ± 2.1	76 ± 22	0.45 ± 0.15	28
U93 7	Lymphoma	10 ± 1.8	281 ± 34	0.99 ± 0.24	62
HEL	Leukemia	40 ± 2.5	65 ± 12	0.65 ± 0.12	54
Raji	Lymphoma	54 ± 21	2332 ± 264	1.6 ± 0.32	75
Cama-1	Breast	65 ± 7.0	280 ± 33	16 ± 1.5	30
SW48	Colon	100 ± 9.1	101 ± 12	2.1 ± 0.21	62
ML-1	Leukemia	98 ± 27	612 ± 55	1.7 ± 0.19	58
HL60	Leukemia	200 ± 54	96 ± 37	3.7 ± 0.61	75
K562	Leukemia	400 ± 34	102 ± 9.8	1.8 ± 0.25	12
MOLT4	Leukemia	1802 ± 125	680 ± 112	10 ± 0.31	80
Jurkat	Leukemia	2000 ± 209	65 ± 15	17.2 ± 0.91	75
PC3	Prostate	7501 ± 550	5600 ± 259	210 ± 22	44
RKO	Colon	9909 ± 980	2100 ± 147	20 ± 24	54
DU145	Prostate	10 000 ± 660	2822 ± 330	300 ± 26	66

Cell line	Tissue	IC₅₀, nM			LINE methylation density %
Cell line	Tissue	DAC	AZA	Ara-C	LINE methylation density %
TF-1	Leukemia	10 ± 2.1	76 ± 22	0.45 ± 0.15	28
U93 7	Lymphoma	10 ± 1.8	281 ± 34	0.99 ± 0.24	62
HEL	Leukemia	40 ± 2.5	65 ± 12	0.65 ± 0.12	54
Raji	Lymphoma	54 ± 21	2332 ± 264	1.6 ± 0.32	75
Cama-1	Breast	65 ± 7.0	280 ± 33	16 ± 1.5	30
SW48	Colon	100 ± 9.1	101 ± 12	2.1 ± 0.21	62
ML-1	Leukemia	98 ± 27	612 ± 55	1.7 ± 0.19	58
HL60	Leukemia	200 ± 54	96 ± 37	3.7 ± 0.61	75
K562	Leukemia	400 ± 34	102 ± 9.8	1.8 ± 0.25	12
MOLT4	Leukemia	1802 ± 125	680 ± 112	10 ± 0.31	80
Jurkat	Leukemia	2000 ± 209	65 ± 15	17.2 ± 0.91	75
PC3	Prostate	7501 ± 550	5600 ± 259	210 ± 22	44
RKO	Colon	9909 ± 980	2100 ± 147	20 ± 24	54
DU145	Prostate	10 000 ± 660	2822 ± 330	300 ± 26	66

Values are presented as the mean plus or minus SEM of 3 independent experiments.