Association between organochlorine exposure and NHL risk in the NCI-SEER study, all genotypes
| Exposure . | Entire study population . | Individuals with genetic information . | ||||||
|---|---|---|---|---|---|---|---|---|
| Ca/Co . | Relative risk (95% CI), %* . | OR (95% CI) . | P . | Ca/Co . | Relative risk (95% CI), %* . | OR (95% CI) . | P . | |
| Treated for termites before 1988† | 220/162 | — | 1.3 (1.0-1.6) | .069 | 196/147 | — | 1.2 (0.9-1.6) | .12 |
| α-Chlordane in carpet dust (ng/g) | 682/513 | 0.6 (0.0-1.2) | — | .051 | 607/462 | 0.6 (0.0-1.2) | — | .067 |
| PCB180 in carpet dust (ng/g) | 682/513 | 0.7 (0.0-1.3) | — | .041 | 607/462 | 0.7 (0.0-1.4) | — | .041 |
| PCB180 in plasma (pg/g lipid) | 100/100 | 8.3 (1.9-14.6) | — | .009 | 93/96 | 8.5 (1.7-15.1) | — | .011 |
| TEQ in plasma (pg/g lipid) | 96/95 | 7.8 (1.1-17.2) | — | .022 | 90/91 | 8.0 (1.0-15.5) | — | .025 |
| Exposure . | Entire study population . | Individuals with genetic information . | ||||||
|---|---|---|---|---|---|---|---|---|
| Ca/Co . | Relative risk (95% CI), %* . | OR (95% CI) . | P . | Ca/Co . | Relative risk (95% CI), %* . | OR (95% CI) . | P . | |
| Treated for termites before 1988† | 220/162 | — | 1.3 (1.0-1.6) | .069 | 196/147 | — | 1.2 (0.9-1.6) | .12 |
| α-Chlordane in carpet dust (ng/g) | 682/513 | 0.6 (0.0-1.2) | — | .051 | 607/462 | 0.6 (0.0-1.2) | — | .067 |
| PCB180 in carpet dust (ng/g) | 682/513 | 0.7 (0.0-1.3) | — | .041 | 607/462 | 0.7 (0.0-1.4) | — | .041 |
| PCB180 in plasma (pg/g lipid) | 100/100 | 8.3 (1.9-14.6) | — | .009 | 93/96 | 8.5 (1.7-15.1) | — | .011 |
| TEQ in plasma (pg/g lipid) | 96/95 | 7.8 (1.1-17.2) | — | .022 | 90/91 | 8.0 (1.0-15.5) | — | .025 |
NHL indicates non-Hodgkin lymphoma; NCI-SEER, National Cancer Institute–Surveillance, Epidemiology, and End Results; OR, odds ratio; CI, confidence interval; PCB, polychlorinated biphenyl; and TEQ, toxic equivalency quotient.
Increase in risk of NHL for each 10% increase in exposure.
Referents are participants whose homes were never treated for termites or were treated only after 1988.