Table 3 Criteria for polycythemia vera... | American Society of Hematology

Table 3

Criteria for polycythemia vera (PV)

Diagnosis requires the presence of both major criteria and one minor criterion or the presence of the first major criterion together with two minor criteria:
Major criteria Hemoglobin > 18.5 g/dL in men, 16.5 g/dL in women or other evidence of increased red cell volume* Presence of JAK2 V617F or other functionally similar mutation such as JAK2 exon 12 mutation
Minor criteria Bone marrow biopsy showing hypercellularity for age with trilineage growth (panmyelosis) with prominent erythroid, granulocytic, and megakaryocytic proliferation Serum erythropoietin level below the reference range for normal Endogenous erythroid colony formation in vitro

Diagnosis requires the presence of both major criteria and one minor criterion or the presence of the first major criterion together with two minor criteria:
Major criteria Hemoglobin > 18.5 g/dL in men, 16.5 g/dL in women or other evidence of increased red cell volume* Presence of JAK2 V617F or other functionally similar mutation such as JAK2 exon 12 mutation
Minor criteria Bone marrow biopsy showing hypercellularity for age with trilineage growth (panmyelosis) with prominent erythroid, granulocytic, and megakaryocytic proliferation Serum erythropoietin level below the reference range for normal Endogenous erythroid colony formation in vitro

Hemoglobin or hematocrit > 99th percentile of method-specific reference range for age, sex, altitude of residence

or hemoglobin > 17 g/dL in men, 15 g/dL in women if associated with a documented and sustained increase of at least 2 g/dL from a person's baseline value that cannot be attributed to correction of iron deficiency

or elevated red cell mass > 25% above mean normal predicted value.

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