Univariate and multivariate analysis for the DC model and leave-one-out risk scores for the PC model
| Covariate . | Time to AML transformation . | Overall survival . | ||||
|---|---|---|---|---|---|---|
| P . | Hazard ratio . | Confidence interval . | P . | Hazard ratio . | Confidence interval . | |
| Univariate hazard ratios | ||||||
| IPSS score | .002* | 1.98 | 1.29-3.05 | .034 | 1.33 | 1.02-1.74 |
| Disease classification | .099 | 1.29 | 0.95-1.73 | .258 | 0.90 | 0.74-1.08 |
| DC model | .001* | 4.29* | 1.94-9.49 | .092 | 1.39 | 0.95-2.05 |
| PC model | < .001* | 2.90* | 1.73-4.87 | .001* | 1.72 | 1.25-2.35 |
| Multicovariate hazard ratios | ||||||
| IPSS score | .604 | 1.15 | 0.69-1.91 | .584 | 1.10 | 0.79-1.53 |
| DC model | .023* | 2.65* | 1.15-6.12 | .628 | 1.11 | 0.73-1.69 |
| PC model | .005* | 2.33* | 1.30-4.18 | .009* | 1.60 | 1.13-2.27 |
| Multicovariate hazard ratios | ||||||
| Blast score | .472 | 1.43 | 0.54-3.79 | .504 | 0.80 | 0.42-1.53 |
| Karyotype score | .806 | 1.21 | 0.26-5.58 | .344 | 1.59 | 0.61-4.16 |
| Cytopenia score | .853 | 0.79 | 0.07-9.24 | .211 | 2.30* | 0.62-8.48 |
| DC model | .015* | 3.58* | 1.28-9.99 | .287 | 1.29 | 0.81-2.05 |
| Multicovariate hazard ratios | ||||||
| Blast score | .130 | 1.90 | 0.83-4.35 | .526 | 0.84 | 0.48-1.46 |
| Karyotype score | .612 | 1.49 | 0.32-6.95 | .313 | 1.65 | 0.63-4.33 |
| Cytopenia score | .828 | 1.28 | 0.14-11.8 | .462 | 1.63 | 0.44-6.05 |
| PC model | .002* | 2.46* | 1.39-4.36 | .004* | 1.66 | 1.17-2.35 |
| Covariate . | Time to AML transformation . | Overall survival . | ||||
|---|---|---|---|---|---|---|
| P . | Hazard ratio . | Confidence interval . | P . | Hazard ratio . | Confidence interval . | |
| Univariate hazard ratios | ||||||
| IPSS score | .002* | 1.98 | 1.29-3.05 | .034 | 1.33 | 1.02-1.74 |
| Disease classification | .099 | 1.29 | 0.95-1.73 | .258 | 0.90 | 0.74-1.08 |
| DC model | .001* | 4.29* | 1.94-9.49 | .092 | 1.39 | 0.95-2.05 |
| PC model | < .001* | 2.90* | 1.73-4.87 | .001* | 1.72 | 1.25-2.35 |
| Multicovariate hazard ratios | ||||||
| IPSS score | .604 | 1.15 | 0.69-1.91 | .584 | 1.10 | 0.79-1.53 |
| DC model | .023* | 2.65* | 1.15-6.12 | .628 | 1.11 | 0.73-1.69 |
| PC model | .005* | 2.33* | 1.30-4.18 | .009* | 1.60 | 1.13-2.27 |
| Multicovariate hazard ratios | ||||||
| Blast score | .472 | 1.43 | 0.54-3.79 | .504 | 0.80 | 0.42-1.53 |
| Karyotype score | .806 | 1.21 | 0.26-5.58 | .344 | 1.59 | 0.61-4.16 |
| Cytopenia score | .853 | 0.79 | 0.07-9.24 | .211 | 2.30* | 0.62-8.48 |
| DC model | .015* | 3.58* | 1.28-9.99 | .287 | 1.29 | 0.81-2.05 |
| Multicovariate hazard ratios | ||||||
| Blast score | .130 | 1.90 | 0.83-4.35 | .526 | 0.84 | 0.48-1.46 |
| Karyotype score | .612 | 1.49 | 0.32-6.95 | .313 | 1.65 | 0.63-4.33 |
| Cytopenia score | .828 | 1.28 | 0.14-11.8 | .462 | 1.63 | 0.44-6.05 |
| PC model | .002* | 2.46* | 1.39-4.36 | .004* | 1.66 | 1.17-2.35 |
P < .05 or hazard ratio > 2.0.