Summary of the effects of KLF2 on the endothelial (phospho-)proteome
| Symbol . | Phosphosite . | P . | Fold . |
|---|---|---|---|
| Repressed proteins | |||
| FAK* | Y576 | < .001 | −3.02 |
| FAK* | S732 | < .001 | −2.81 |
| CDK1/2 | T14 + Y15 | .009 | −1.67 |
| Hsp27* | S82 | .015 | −1.93 |
| FKHRL1 | T32 | .016 | −3.65 |
| Hsp27* | S82 | .017 | −2.41 |
| CDK7 | Pan-specific | .020 | −1.45 |
| HspBP1 | Pan-specific | .022 | −1.49 |
| c-Jun† | S63 | .032 | −3.54 |
| Crystallin aB* | S19 | .035 | −1.57 |
| IRAK4 | Pan-specific | .043 | −4.10 |
| PKCq | S676 | .047 | −1.39 |
| Ksr1† | Pan-specific | .049 | −1.68 |
| Rb | S780 | .050 | −1.62 |
| Induced proteins | |||
| PKCg | T514 | .004 | 2.24 |
| Abl | Y412 | .005 | 1.62 |
| RSK1/2† | S363/S369 | .012 | 3.16 |
| Src* | Pan-specific | .018 | 1.61 |
| HO2 | Pan-specific | .027 | 2.04 |
| ATF2† | T51 + T53 | .027 | 1.44 |
| p38a† | Pan-specific | .034 | 1.48 |
| PKCb2 | T641 | .038 | 2.42 |
| STAT5A | Y694 | .041 | 3.41 |
| S6Ka† | T389 | .046 | 2.53 |
| Symbol . | Phosphosite . | P . | Fold . |
|---|---|---|---|
| Repressed proteins | |||
| FAK* | Y576 | < .001 | −3.02 |
| FAK* | S732 | < .001 | −2.81 |
| CDK1/2 | T14 + Y15 | .009 | −1.67 |
| Hsp27* | S82 | .015 | −1.93 |
| FKHRL1 | T32 | .016 | −3.65 |
| Hsp27* | S82 | .017 | −2.41 |
| CDK7 | Pan-specific | .020 | −1.45 |
| HspBP1 | Pan-specific | .022 | −1.49 |
| c-Jun† | S63 | .032 | −3.54 |
| Crystallin aB* | S19 | .035 | −1.57 |
| IRAK4 | Pan-specific | .043 | −4.10 |
| PKCq | S676 | .047 | −1.39 |
| Ksr1† | Pan-specific | .049 | −1.68 |
| Rb | S780 | .050 | −1.62 |
| Induced proteins | |||
| PKCg | T514 | .004 | 2.24 |
| Abl | Y412 | .005 | 1.62 |
| RSK1/2† | S363/S369 | .012 | 3.16 |
| Src* | Pan-specific | .018 | 1.61 |
| HO2 | Pan-specific | .027 | 2.04 |
| ATF2† | T51 + T53 | .027 | 1.44 |
| p38a† | Pan-specific | .034 | 1.48 |
| PKCb2 | T641 | .038 | 2.42 |
| STAT5A | Y694 | .041 | 3.41 |
| S6Ka† | T389 | .046 | 2.53 |
The Bayesian P value and -fold induction by KLF2 are indicated, with repressed proteins listed first and induced proteins second. The proteins are ranked according to P value.
CDK7 indicates cyclin-dependent kinase 7; FAK, focal adhesion kinase; FKHRL1, forkhead (Drosophila) homolog (rhabdomyosarcoma)-like 1; Hsp27, heat shock protein 27; IRAK4, interleukin-1 receptor–associated kinase 4; KLF2, Krüppel-like factor 2; MAPK, mitogen-activated protein kinase; PKCg, protein kinase Cγ; PKCq, protein kinase Cθ; and Rb, retinoblastoma protein.
Proteins implicated in actin cytoskeleton/integrin signaling.
Proteins implicated in MAPK signaling.