Selected genes that are differentially expressed between In(Lu) and control cells
| Gene symbol . | Gene title . | Day 6 fold change . | Day 11 fold change . |
|---|---|---|---|
| Antigen processing and presentation | |||
| ARTS-1 | Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator | 4.6 | 2.4 |
| HLA-A | Major histocompatibility complex, class I, A | 1.5 | 1.6 |
| HLA-B | Major histocompatibility complex, class I, B | 1.1 | 2.1 |
| HLA-DPB1 | Major histocompatibility complex, class II, DP beta 1 | 1.8 | 1.6 |
| HLA-DRA | Major histocompatibility complex, class II, DR alpha | 2.0 | 1.8 |
| HLA-DRB1 | Major histocompatibility complex, class II, DR beta 1 | 1.9 | 1.3 |
| HLA-DRB4 | Major histocompatibility complex, class II, DR beta 4 | 1.7 | 1.0 |
| HLA-G | HLA-G histocompatibility antigen, class I, G | 1.2 | 1.8 |
| Defense response | |||
| ECRP | Eosinophil cationic related protein | 2.5 | 3.0 |
| ELA2 | Elastase 2, neutrophil | 3.4 | 2.8 |
| FCER1A | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | 1.8 | 1.2 |
| IL4R | Interleukin 4 receptor | 2.2 | 2.2 |
| MPO | Myeloperoxidase | 3.0 | 1.6 |
| NCF4 | Neutrophil cytosolic factor 4, 40 kDa | 2.1 | 1.5 |
| PRG3 | Proteoglycan 3 | 1.5 | 1.6 |
| RNASE2 | Ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) | 1.7 | 1.8 |
| TPSAB1 | Tryptase alpha/beta 1 | 4.6 | 3.9 |
| TPSAB1/TPSB2 | Tryptase alpha/beta 1 / tryptase beta 2 | 4.5 | 4.0 |
| TPSB2 | Tryptase beta 2 | 5.0 | 3.5 |
| Heme/globin synthesis | |||
| AHSP | Alpha hemoglobin stabilizing protein | −1.8 | −1.1 |
| ALAD | Aminolevulinate, delta-, dehydratase | −2.1 | −1.3 |
| ALAS2 | Aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia) | −2.1 | −1.0 |
| HBE1 | Hemoglobin, epsilon 1 | −1.8 | −1.3 |
| UROD | Uroporphyrinogen decarboxylase | −1.6 | −1.2 |
| Blood group antigens/erythroid factors | |||
| ANK1 | Ankyrin 1, erythrocytic | −1.6 | −1.2 |
| AQP1 | Aquaporin 1 (Colton blood group) | −3.0 | −1.7 |
| ARG1 | Arginase, liver | −2.3 | −1.6 |
| ART4 | ADP-ribosyltransferase 4 (Dombrock blood group) | −2.6 | −1.3 |
| BCAM | Basal cell adhesion molecule (Lutheran blood group) | −1.5 | −3.5 |
| BSG | Basigin (Ok blood group) | −1.7 | −1.3 |
| CD44 | CD44 molecule (Indian blood group) | −1.7 | −1.9 |
| DARC | Duffy blood group, chemokine receptor | −1.7 | −1.3 |
| EPB42 | Erythrocyte membrane protein band 4.2 | −1.8 | −1.1 |
| EPOR | Erythropoietin receptor | −1.9 | −1.3 |
| ERMAP | Erythroblast membrane-associated protein (Scianna blood group) | −1.5 | −1.4 |
| GYPA | Glycophorin A (MNS blood group) | −1.5 | −1.1 |
| NFE2 | Nuclear factor (erythroid-derived 2), 45kDa | −1.5 | −1.2 |
| PKLR | Pyruvate kinase, liver and RBC | −2.6 | −1.7 |
| SLC4A1 | Solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) | −3.1 | −1.1 |
| TMOD1 | Tropomodulin 1 | −2.0 | −1.3 |
| Gene symbol . | Gene title . | Day 6 fold change . | Day 11 fold change . |
|---|---|---|---|
| Antigen processing and presentation | |||
| ARTS-1 | Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator | 4.6 | 2.4 |
| HLA-A | Major histocompatibility complex, class I, A | 1.5 | 1.6 |
| HLA-B | Major histocompatibility complex, class I, B | 1.1 | 2.1 |
| HLA-DPB1 | Major histocompatibility complex, class II, DP beta 1 | 1.8 | 1.6 |
| HLA-DRA | Major histocompatibility complex, class II, DR alpha | 2.0 | 1.8 |
| HLA-DRB1 | Major histocompatibility complex, class II, DR beta 1 | 1.9 | 1.3 |
| HLA-DRB4 | Major histocompatibility complex, class II, DR beta 4 | 1.7 | 1.0 |
| HLA-G | HLA-G histocompatibility antigen, class I, G | 1.2 | 1.8 |
| Defense response | |||
| ECRP | Eosinophil cationic related protein | 2.5 | 3.0 |
| ELA2 | Elastase 2, neutrophil | 3.4 | 2.8 |
| FCER1A | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | 1.8 | 1.2 |
| IL4R | Interleukin 4 receptor | 2.2 | 2.2 |
| MPO | Myeloperoxidase | 3.0 | 1.6 |
| NCF4 | Neutrophil cytosolic factor 4, 40 kDa | 2.1 | 1.5 |
| PRG3 | Proteoglycan 3 | 1.5 | 1.6 |
| RNASE2 | Ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) | 1.7 | 1.8 |
| TPSAB1 | Tryptase alpha/beta 1 | 4.6 | 3.9 |
| TPSAB1/TPSB2 | Tryptase alpha/beta 1 / tryptase beta 2 | 4.5 | 4.0 |
| TPSB2 | Tryptase beta 2 | 5.0 | 3.5 |
| Heme/globin synthesis | |||
| AHSP | Alpha hemoglobin stabilizing protein | −1.8 | −1.1 |
| ALAD | Aminolevulinate, delta-, dehydratase | −2.1 | −1.3 |
| ALAS2 | Aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia) | −2.1 | −1.0 |
| HBE1 | Hemoglobin, epsilon 1 | −1.8 | −1.3 |
| UROD | Uroporphyrinogen decarboxylase | −1.6 | −1.2 |
| Blood group antigens/erythroid factors | |||
| ANK1 | Ankyrin 1, erythrocytic | −1.6 | −1.2 |
| AQP1 | Aquaporin 1 (Colton blood group) | −3.0 | −1.7 |
| ARG1 | Arginase, liver | −2.3 | −1.6 |
| ART4 | ADP-ribosyltransferase 4 (Dombrock blood group) | −2.6 | −1.3 |
| BCAM | Basal cell adhesion molecule (Lutheran blood group) | −1.5 | −3.5 |
| BSG | Basigin (Ok blood group) | −1.7 | −1.3 |
| CD44 | CD44 molecule (Indian blood group) | −1.7 | −1.9 |
| DARC | Duffy blood group, chemokine receptor | −1.7 | −1.3 |
| EPB42 | Erythrocyte membrane protein band 4.2 | −1.8 | −1.1 |
| EPOR | Erythropoietin receptor | −1.9 | −1.3 |
| ERMAP | Erythroblast membrane-associated protein (Scianna blood group) | −1.5 | −1.4 |
| GYPA | Glycophorin A (MNS blood group) | −1.5 | −1.1 |
| NFE2 | Nuclear factor (erythroid-derived 2), 45kDa | −1.5 | −1.2 |
| PKLR | Pyruvate kinase, liver and RBC | −2.6 | −1.7 |
| SLC4A1 | Solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) | −3.1 | −1.1 |
| TMOD1 | Tropomodulin 1 | −2.0 | −1.3 |
Differentially expressed genes are grouped according to gene ontology terms showing enrichment. Separate values are shown for fold differences in expression (In(Lu) value divided by control value) in cells at day 6 and at day 11. Genes showing higher expression in In(Lu) cells than in controls have positive values; genes showing lower expression in In(Lu) cells than in controls have negative values. Average values have been taken for genes that are represented more than once on the arrays.