Proportion of patients with neurocognitive test scores 1 or more standard deviation worse than the normative mean, stratified by corticosteroid randomization
| Domain and instrument/scale . | Dexamethasone (%) . | Prednisone (%) . | P* . |
|---|---|---|---|
| Intelligence | |||
| WISC-IV | |||
| Full scale IQ | 4/51 (7.8) | 2/41 (4.9) | .69 |
| Academic achievement | |||
| WIAT-IIA | |||
| Word reading | 5/51 (9.8) | 2/41 (4.9) | .46 |
| Numeric operations | 8/51 (15.7) | 7/41 (17.1) | .86 |
| Spelling | 4/51 (7.8) | 2/41 (4.9) | .69 |
| Processing speed | |||
| WISC-IV | |||
| Processing speed index | 13/51 (25.5) | 7/41 (17.1) | .31 |
| Attention-concentration | |||
| CPT-II† | |||
| Omissions | 0/46 (0.0) | 0/36 (0.0) | NA |
| Commissions | 19/46 (41.3) | 9/36 (25.0) | .12 |
| Reaction time | 14/46 (30.4) | 9/36 (25.0) | .59 |
| Variability T-score | 15/46 (32.6) | 11/36 (30.6) | .84 |
| Memory | |||
| CMS† | |||
| Visual immediate index | 2/46 (4.3) | 2/38 (5.3) | .999 |
| Verbal immediate index | 4/46 (8.7) | 4/38 (10.5) | .78 |
| General memory index | 2/46 (4.3) | 3/38 (7.9) | .65 |
| Working memory | |||
| WISC-IV | |||
| Working memory | 6/51 (11.8) | 2/41 (4.9) | .29 |
| Visual motor integration | |||
| Beery | |||
| Visual motor integration | 11/51 (21.6) | 5/41 (12.0) | .24 |
| Domain and instrument/scale . | Dexamethasone (%) . | Prednisone (%) . | P* . |
|---|---|---|---|
| Intelligence | |||
| WISC-IV | |||
| Full scale IQ | 4/51 (7.8) | 2/41 (4.9) | .69 |
| Academic achievement | |||
| WIAT-IIA | |||
| Word reading | 5/51 (9.8) | 2/41 (4.9) | .46 |
| Numeric operations | 8/51 (15.7) | 7/41 (17.1) | .86 |
| Spelling | 4/51 (7.8) | 2/41 (4.9) | .69 |
| Processing speed | |||
| WISC-IV | |||
| Processing speed index | 13/51 (25.5) | 7/41 (17.1) | .31 |
| Attention-concentration | |||
| CPT-II† | |||
| Omissions | 0/46 (0.0) | 0/36 (0.0) | NA |
| Commissions | 19/46 (41.3) | 9/36 (25.0) | .12 |
| Reaction time | 14/46 (30.4) | 9/36 (25.0) | .59 |
| Variability T-score | 15/46 (32.6) | 11/36 (30.6) | .84 |
| Memory | |||
| CMS† | |||
| Visual immediate index | 2/46 (4.3) | 2/38 (5.3) | .999 |
| Verbal immediate index | 4/46 (8.7) | 4/38 (10.5) | .78 |
| General memory index | 2/46 (4.3) | 3/38 (7.9) | .65 |
| Working memory | |||
| WISC-IV | |||
| Working memory | 6/51 (11.8) | 2/41 (4.9) | .29 |
| Visual motor integration | |||
| Beery | |||
| Visual motor integration | 11/51 (21.6) | 5/41 (12.0) | .24 |
Comparison between dexamethasone and prednisone groups.
Ten patients (5 in dexamethasone, 5 in prednisone) did not complete the CPT-II. Eight patients (5 in dexamethasone, 3 in prednisone) did not complete the CMS. However the rates of completion were similar between the 2 groups for each of the instruments.