Association between FGA and FGG haplotypes and juvenile VT
| Block . | Haplotype* . | Frequency . | T:U* . | χ2 . | P . |
|---|---|---|---|---|---|
| All VT | |||||
| FGA haplotypes | |||||
| H1 | AACT | 0.324 | 62.0: 32.6 | 9.134 | .002‡ |
| H2 | GACC | 0.28 | 39.7: 51.7 | 1.576 | .209 |
| H3 | GATC | 0.145 | 17.0: 32.0 | 4.591 | .0321 |
| H4 | GGCC | 0.138 | 27.3: 23.3 | 0.317 | .574 |
| H5 | GACT | 0.102 | 19.0: 22.4 | 0.278 | .598 |
| FGG haplotypes | |||||
| H1 | ACC | 0.384 | 51.0: 58.0 | 0.447 | .508 |
| H2 | ATC | 0.319 | 60.0: 32.0 | 8.523 | .003‡ |
| H3 | GCC | 0.248 | 28.0: 48.0 | 5.277 | .022 |
| H4 | ACT | 0.047 | 9.0: 9.0 | 0 | 1 |
| FVLeiden-negative families | |||||
| FGA haplotypes | |||||
| H1 | AACT | 0.308 | 55.0: 24.3 | 11.85 | .001‡ |
| H2 | GACC | 0.281 | 29.0: 52.0 | 6.532 | .011 |
| H3 | GATC | 0.154 | 17.0: 22.0 | 0.64 | .423 |
| H4 | GGCC | 0.139 | 20.0: 20.0 | 0 | 1 |
| H5 | GACT | 0.105 | 17.0: 16.7 | 0.003 | .953 |
| FGG haplotypes | |||||
| H1 | ACC | 0.378 | 37.1: 57.0 | 4.233 | .040 |
| H2 | ATC† | 0.315 | 54.9: 24.0 | 12.157 | .001‡ |
| H3 | GCC | 0.256 | 30.9: 36.0 | 0.38 | .537 |
| H4 | ACT | 0.049 | 6.0: 11.0 | 1.471 | .225 |
| Block . | Haplotype* . | Frequency . | T:U* . | χ2 . | P . |
|---|---|---|---|---|---|
| All VT | |||||
| FGA haplotypes | |||||
| H1 | AACT | 0.324 | 62.0: 32.6 | 9.134 | .002‡ |
| H2 | GACC | 0.28 | 39.7: 51.7 | 1.576 | .209 |
| H3 | GATC | 0.145 | 17.0: 32.0 | 4.591 | .0321 |
| H4 | GGCC | 0.138 | 27.3: 23.3 | 0.317 | .574 |
| H5 | GACT | 0.102 | 19.0: 22.4 | 0.278 | .598 |
| FGG haplotypes | |||||
| H1 | ACC | 0.384 | 51.0: 58.0 | 0.447 | .508 |
| H2 | ATC | 0.319 | 60.0: 32.0 | 8.523 | .003‡ |
| H3 | GCC | 0.248 | 28.0: 48.0 | 5.277 | .022 |
| H4 | ACT | 0.047 | 9.0: 9.0 | 0 | 1 |
| FVLeiden-negative families | |||||
| FGA haplotypes | |||||
| H1 | AACT | 0.308 | 55.0: 24.3 | 11.85 | .001‡ |
| H2 | GACC | 0.281 | 29.0: 52.0 | 6.532 | .011 |
| H3 | GATC | 0.154 | 17.0: 22.0 | 0.64 | .423 |
| H4 | GGCC | 0.139 | 20.0: 20.0 | 0 | 1 |
| H5 | GACT | 0.105 | 17.0: 16.7 | 0.003 | .953 |
| FGG haplotypes | |||||
| H1 | ACC | 0.378 | 37.1: 57.0 | 4.233 | .040 |
| H2 | ATC† | 0.315 | 54.9: 24.0 | 12.157 | .001‡ |
| H3 | GCC | 0.256 | 30.9: 36.0 | 0.38 | .537 |
| H4 | ACT | 0.049 | 6.0: 11.0 | 1.471 | .225 |
T:U indicates ratio of transmissions to nontransmissions.
The haplotype association for FVLeiden-positive families is not available because of the small sample size.
The H2-ATC haplotype in FGG is equivalent to H2-GAT haplotype described by Uitte de Willige et al.5 The different annotation is the result of TaqMan primers being designed on the opposite DNA strand.
P value indicates statistical significance.