Incidence of major chromosomal abnormalities in adult ALL observed in this study compared with previously published clinical trials
| Study . | Reference . | Patients tested, n . | t(9;22) % . | t(4;11) % . | t(1;19) % . | t(8;14) % . | t(14;18) % . | HeH, %* . | HoTr, %† . | Complex, %‡ . | Normal, %§ . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| This study (15- to 59-year-old patients only) | NA | 236 | 15 | 6 | 4 | 4 | 1 | 9 | 2 | 4 | 29 |
| MRC UKALLXA | 17 | 350 | 11 | 3 | 3 | NA | NA | 8 | NA | NA | 34 |
| UKALLXII/ECOG2993 | 2 | 1373 | 19 | 4 | 2 | 1 | NA | 6 | 2 | 3 | 14 |
| CALGB | 22 | 256 | 26 | 5 | NA | NA | NA | NA | NA | NA | 25 |
| GIMEMA 0496 | 20 | 386 | 26 | 7 | 2 | NA | NA | NA | NA | NA | 26 |
| SWOG 9400 | 3 | 140 | 26 | 5 | 5 | NA | NA | NA | NA | NA | 22 |
| GFCH | 21 | 443 | 29 | 4 | 3 | 5 | NA | 7 | NA | NA | 15 |
| Study . | Reference . | Patients tested, n . | t(9;22) % . | t(4;11) % . | t(1;19) % . | t(8;14) % . | t(14;18) % . | HeH, %* . | HoTr, %† . | Complex, %‡ . | Normal, %§ . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| This study (15- to 59-year-old patients only) | NA | 236 | 15 | 6 | 4 | 4 | 1 | 9 | 2 | 4 | 29 |
| MRC UKALLXA | 17 | 350 | 11 | 3 | 3 | NA | NA | 8 | NA | NA | 34 |
| UKALLXII/ECOG2993 | 2 | 1373 | 19 | 4 | 2 | 1 | NA | 6 | 2 | 3 | 14 |
| CALGB | 22 | 256 | 26 | 5 | NA | NA | NA | NA | NA | NA | 25 |
| GIMEMA 0496 | 20 | 386 | 26 | 7 | 2 | NA | NA | NA | NA | NA | 26 |
| SWOG 9400 | 3 | 140 | 26 | 5 | 5 | NA | NA | NA | NA | NA | 22 |
| GFCH | 21 | 443 | 29 | 4 | 3 | 5 | NA | 7 | NA | NA | 15 |
ALL indicates acute lymphoblastic leukemia; CALGB, Cancer and Leukemia Group B; GFCH, Français de Cytogénétique Hématologique; GIMEMA, Gruppo Italiano Malattie Ematologiche Ddell'Adulto; HeH, high hyperdiploidy; HoTr, low hypodiploidy/near triploidy; MRC, Medical Research Council; NA, not available; SWOG, Southwest Oncology Group.
High hyperdiploidy (51-65 chromosomes).
Low hyperdiploidy (30-39 chromosomes)/near triploidy (60-78 chromosomes).
Complex karyotype defined as 5 or more chromosomal abnormalities in the absence of an established cytogenetic subgroup.
A total of 20 or more normal metaphases in the absence of any clonal chromosomal abnormality.