Table 1 Specificity profiles of the PI3K... | American Society of Hematology

Table 1

Specificity profiles of the PI3K inhibitors used in this study, based on IC₅₀ values (μM)

Name	p110α	p110β	p110γ	p110δ	Comment
Ly294002	9.3	2.9	38	6.0	Pan-PI3K inhibitor
PIK-90	0.011	0.35	0.018	0.058	Low mTOR activity, cell permeable
PI-103	0.008	0.088	0.15	0.048	Targets PI3KC2β, mTORC2, DNA-PK, p235
TGX115	61	0.13	100	0.63	p110β- and δ-selective
IC87114	200	16	61	0.13	Selective p110δ inhibitor, cell permeable

Name	p110α	p110β	p110γ	p110δ	Comment
Ly294002	9.3	2.9	38	6.0	Pan-PI3K inhibitor
PIK-90	0.011	0.35	0.018	0.058	Low mTOR activity, cell permeable
PI-103	0.008	0.088	0.15	0.048	Targets PI3KC2β, mTORC2, DNA-PK, p235
TGX115	61	0.13	100	0.63	p110β- and δ-selective
IC87114	200	16	61	0.13	Selective p110δ inhibitor, cell permeable

The IC₅₀ values and the key characteristics of the inhibitors are based on the data published by Knight et al⁵³ and Marone et al.³⁵