GSK690693 inhibits proliferation of ALL cells from both B-cell and T-cell origin
| Cell line . | Cell type . | EC50, nM . |
|---|---|---|
| KARPAS-231 | B cell | 41 |
| CCRFSB | B cell | 155 |
| SUP B15 | B cell | 197 |
| SD-1 | B cell | 320 |
| RS4;11 | B cell | 654 |
| MN-60 | B cell | 3602 |
| Tanoue | B cell | 4517 |
| RCH-ACV | pre-B cell | 152 |
| SEM | pre-B cell | 202 |
| KASUMI-2 | pre-B cell | 225 |
| REH | pre-B cell | 288 |
| 697 | pre-B cell | 338 |
| NALM-6 | pre-B cell | 421 |
| MHH-CALL–3 | pre-B cell | 812 |
| MHH-CALL–2 | pre-B cell | 2114 |
| J.GAMMA-1 | T cell | 65 |
| JR45.01 | T cell | 68 |
| A3 | T cell | 69 |
| I 2.1 | T cell | 73 |
| MOLT-3 | T cell | 74 |
| P116 | T cell | 78 |
| J.Cam1.6 | T cell | 79 |
| I 9.2 | T cell | 80 |
| LOUCY | T cell | 117 |
| J.RT3-T3.5 | T cell | 123 |
| 8E5 | T cell | 163 |
| Jurkat | T cell | 225 |
| MOLT-4 | T cell | 232 |
| Molt-16 | T cell | 241 |
| CEM/C3 | T cell | 257 |
| CEM/C2 | T cell | 271 |
| CCRFCEM | T cell | 327 |
| CEM/C1 | T cell | 382 |
| SUPTI[VB] | T cell | 619 |
| CCRF–HSB-2 | T cell | 2117 |
| Cell line . | Cell type . | EC50, nM . |
|---|---|---|
| KARPAS-231 | B cell | 41 |
| CCRFSB | B cell | 155 |
| SUP B15 | B cell | 197 |
| SD-1 | B cell | 320 |
| RS4;11 | B cell | 654 |
| MN-60 | B cell | 3602 |
| Tanoue | B cell | 4517 |
| RCH-ACV | pre-B cell | 152 |
| SEM | pre-B cell | 202 |
| KASUMI-2 | pre-B cell | 225 |
| REH | pre-B cell | 288 |
| 697 | pre-B cell | 338 |
| NALM-6 | pre-B cell | 421 |
| MHH-CALL–3 | pre-B cell | 812 |
| MHH-CALL–2 | pre-B cell | 2114 |
| J.GAMMA-1 | T cell | 65 |
| JR45.01 | T cell | 68 |
| A3 | T cell | 69 |
| I 2.1 | T cell | 73 |
| MOLT-3 | T cell | 74 |
| P116 | T cell | 78 |
| J.Cam1.6 | T cell | 79 |
| I 9.2 | T cell | 80 |
| LOUCY | T cell | 117 |
| J.RT3-T3.5 | T cell | 123 |
| 8E5 | T cell | 163 |
| Jurkat | T cell | 225 |
| MOLT-4 | T cell | 232 |
| Molt-16 | T cell | 241 |
| CEM/C3 | T cell | 257 |
| CEM/C2 | T cell | 271 |
| CCRFCEM | T cell | 327 |
| CEM/C1 | T cell | 382 |
| SUPTI[VB] | T cell | 619 |
| CCRF–HSB-2 | T cell | 2117 |
Antiproliferative activity of GSK690693 was determined in a 72-hour proliferation assay against various ALL cell lines. EC50 was determined as described in “Cell proliferation assay.” Data represent the average value from 2 or more independent experiments.