Table 2

Frequent examples of differential diagnosis of ITP and potential alternative causes of thrombocytopenia identified by patient history

  • Previously diagnosed or possible high risk of conditions that may be associated with autoimmune thrombocytopenia, for example, HIV, HCV, or other infection; other autoimmune/immunodeficiency disorders (including systemic lupus erythematosus [SLE]); malignancy (eg, lymphoproliferative disorders); recent vaccination

  • Liver disease (including alcoholic liver cirrhosis)

  • Drugs (prescription or non-prescription), alcohol abuse, consumption of quinine (tonic water), exposure to environmental toxins

  • Bone marrow diseases including myelodysplastic syndromes, leukemias, other malignancies, and fibrosis, aplastic anemia, and megaloblastic anemia

  • Recent transfusions (possibility of posttransfusion purpura) and recent immunizations

  • Inherited thrombocytopenia: thrombocytopenia-absent radius (TAR) syndrome, radioulnar synostosis, congenital amegakaryocytic thrombocytopenia, Wiskott-Aldrich syndrome, MYH9-related disease, Bernard-Soulier syndrome, type IIB von Willebrand disease

 
  • Previously diagnosed or possible high risk of conditions that may be associated with autoimmune thrombocytopenia, for example, HIV, HCV, or other infection; other autoimmune/immunodeficiency disorders (including systemic lupus erythematosus [SLE]); malignancy (eg, lymphoproliferative disorders); recent vaccination

  • Liver disease (including alcoholic liver cirrhosis)

  • Drugs (prescription or non-prescription), alcohol abuse, consumption of quinine (tonic water), exposure to environmental toxins

  • Bone marrow diseases including myelodysplastic syndromes, leukemias, other malignancies, and fibrosis, aplastic anemia, and megaloblastic anemia

  • Recent transfusions (possibility of posttransfusion purpura) and recent immunizations

  • Inherited thrombocytopenia: thrombocytopenia-absent radius (TAR) syndrome, radioulnar synostosis, congenital amegakaryocytic thrombocytopenia, Wiskott-Aldrich syndrome, MYH9-related disease, Bernard-Soulier syndrome, type IIB von Willebrand disease

 

Refer also to supplemental Document 2.

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