Demographics of patients with Crohn disease undergoing HSCT
| Patient . | Age, y/sex . | CDAI score (CSI) . | Disease duration, y/location . | Fistulae (stricture) fever . | Prior surgery . | Narcotics . | Prior medications/nutrition support . | Prior treatment complications . |
|---|---|---|---|---|---|---|---|---|
| 1 | 21/F | 305 (32) | 10 A/SB/C | Anovaginal fever | Sig rsx SB rsx | yes | CCS, 6-MP, MTX, IFX, AZA, MES, MNZ, TPN | Rectal bleeding (MES) |
| 2 | 16/M | 271 (33) | 7 SB/C | Perianal | None | no | CCS, MES, MTX, AZA, 6-MP, IFX, CPX, MNZ, tube feeding | None |
| 3 | 38/F | 277 (30) | 20 SB/C/A | Perianal fever | IC rsx Sig rsx | yes | CCS, MES, 6-MP, MTX, IFX, CPX, MNZ | Bone marrow depression (6-MP) Thrombocytopenia Leukopenia (MTX) |
| 4 | 27/F | 285 (23) | 12 C/A | Perianal | A | no | CCS, MES, 6-MP, MTX, AZA, MNZ, CPX, IFX, Interleukin-11 | Liver injury (AZA) Allergy (IFX) Flu-like (6-MP) |
| 5 | 35/M | 307 (31) | 12 C/SB/A | Perianal SB-SB Fever | A | yes | CCS, MES, AZA, 6-MP, MTX, CSA, CPX, IFX | None |
| 6 | 27/F | 253 (17) | 6 C/SB/A | Rectovaginal | A, SB rsx IC rsx | no | CCS, MES, AZA, 6-MP, MTX, IFX, ETN, MNZ, CPX, TPN | Anaphylaxis (IFX) Pancreatitis (AZA, MNZ) |
| 7 | 25/M | 282 (22) | 13 SB/C/A | Perianal | Sig rsx Ileostomy | yes | CCS, 6-MP, MTX, MNZ, CPX, MMF, IFX | None |
| 8 | 15/M | 250 (23) | 8 A/SB/C | None | SB rsx (2) | no | CCS, MES, MTX, 6-MP, CPX, MNZ, IFX, jejunal feeding | Pancreatitis (6-MP) Anaphylaxis (IFX) |
| 9 | 31/F | 268 (23) | 10 SB/C/A | Anorectal fever | Sig rsx SB rsx Div colost | yes | CCS, MES, AZA, MNZ, CPX, IFX, TPN | Allergy (MNZ) |
| 10 | 37/M | 298 (22) | 6 A/C | Perianal fever | None | no | CCS, MES, MTX, 6-MP, IFX, CPX, MNZ | None |
| 11 | 16/M | 256 (23) | 1.5 SB/C | Enterocut fever | None | yes | CCS, MES, 6-MP, CPX, IFX. TPN | None |
| 12 | 27/M | 298 (29) | 14 A/C/SB | Enterocut fever | Cecal rsx Ileostomy Standard colectomy | yes | CCS, MES, AZA, 6-MP, MTZ, IFX, TCL | None |
| 13 | 25/F | 207 (20) | 12 SB/C | None | Ileectomy Proctectomy | yes | CCS, AZA, SFD, MES, CSA, IFX | Tremor and mental status change (CSA) |
| 14 | 18/F | 210 (29) | 12 A/SB/C | Perianal | None | yes | CCS, AZA, MTX, 6-MP, TCL, MES, MNZ, IFX, NTL | Pancreatitis (AZA) Anaphylaxis (IFX) Renal failure (TCL) |
| 15 | 28/M | 264 (22) | 10 SB/C | No | Ileal rsx (3) | yes | CCS, MES, AZA, 6-MP, MTX, MNZ, CPX, CSA, IFX | None |
| 16 | 27/F | 199 (18) | 8 C/A | Perianal rectovaginal | Partial colectomy Total colectomy | yes | CCS, MES, 6-MP, AZA, MTX, MNZ, MTX, CSA, IFX | Steroid-induced psychosis |
| 17 | 16/M | 233 (24) | 8 A/C/SB | Perianal | None | Yes | CCS, MES, 6-MP, AZA, CYC, MNZ, CPX, THA, MTX, IFX, ADL, TPN | Neutropenia (6-MP) Liver toxicity (CSA) Arrythmia and anaphylaxis (IFX) Peripheral neuropathy (THA) |
| 18 | 24/F | 191 (17) | 6 Duod/C | None | None | Yes | CCS, MES, 6-MP, AZA, MTX, THA, CPX, MNZ, IFX | Anaphylaxis (IFX) Mental status change (CCS and MNZ) Seizures (CPX) |
| 19 | 21/M | 101 (23) | 6 C/A | Enterovesical Perianal | None | No | CCS, MES, 6-MP, AZA, MNZ, IFX | Anaphylaxis (IFX) Pancreatitis (6-MP) |
| 20 | 29/M | 228 (21) | 9 Ileal/C/A | Perirectal | Div colost Ileocolonic rsx | Yes | CCS, AZA, IFX, CPX, MNZ | None |
| 21 | 42/F | 91 (17) | 8 C/SB | None | Proctocolectomy SB rsx (3) | Yes | CCS, MES, 6-MP, MMF, AZA, MTX, CPX, MNZ, IFX, ADL | Petechiae (6-MP) Serum sickness (IFX) Fever and vomiting (AZA) |
| 22 | 52/M | 168 (20) | 27 SB/C | None | SB rsx (4) | Yes | CCS, MES, CPX, MNZ 6-MP, AZA, MTX, IFX, ADL | Anaphylaxis (IFX)Flu-like symptoms (ADL) |
| 23 | 25/F | 237 (24) | 8 C/A | Perianal fever | Fistulae | Yes | CCS, MES, MNZ, CPX, AZA, 6-MP, MTX, IFX, ADL | Edema (MES) Breathing problems (IFX) Peripheral neuropathy (MNZ) |
| 24 | 31/F | 181 (19) | 17 A/SB/C | Perianal rectovaginal (SB stx, Rectal stx) | Ileostomy Partial colectomy X2 SB rsx X2 | Yes | CCS, AZA, CSA, IFX, ADL, MNZ, TPN | Sepsis (IFX) |
| Patient . | Age, y/sex . | CDAI score (CSI) . | Disease duration, y/location . | Fistulae (stricture) fever . | Prior surgery . | Narcotics . | Prior medications/nutrition support . | Prior treatment complications . |
|---|---|---|---|---|---|---|---|---|
| 1 | 21/F | 305 (32) | 10 A/SB/C | Anovaginal fever | Sig rsx SB rsx | yes | CCS, 6-MP, MTX, IFX, AZA, MES, MNZ, TPN | Rectal bleeding (MES) |
| 2 | 16/M | 271 (33) | 7 SB/C | Perianal | None | no | CCS, MES, MTX, AZA, 6-MP, IFX, CPX, MNZ, tube feeding | None |
| 3 | 38/F | 277 (30) | 20 SB/C/A | Perianal fever | IC rsx Sig rsx | yes | CCS, MES, 6-MP, MTX, IFX, CPX, MNZ | Bone marrow depression (6-MP) Thrombocytopenia Leukopenia (MTX) |
| 4 | 27/F | 285 (23) | 12 C/A | Perianal | A | no | CCS, MES, 6-MP, MTX, AZA, MNZ, CPX, IFX, Interleukin-11 | Liver injury (AZA) Allergy (IFX) Flu-like (6-MP) |
| 5 | 35/M | 307 (31) | 12 C/SB/A | Perianal SB-SB Fever | A | yes | CCS, MES, AZA, 6-MP, MTX, CSA, CPX, IFX | None |
| 6 | 27/F | 253 (17) | 6 C/SB/A | Rectovaginal | A, SB rsx IC rsx | no | CCS, MES, AZA, 6-MP, MTX, IFX, ETN, MNZ, CPX, TPN | Anaphylaxis (IFX) Pancreatitis (AZA, MNZ) |
| 7 | 25/M | 282 (22) | 13 SB/C/A | Perianal | Sig rsx Ileostomy | yes | CCS, 6-MP, MTX, MNZ, CPX, MMF, IFX | None |
| 8 | 15/M | 250 (23) | 8 A/SB/C | None | SB rsx (2) | no | CCS, MES, MTX, 6-MP, CPX, MNZ, IFX, jejunal feeding | Pancreatitis (6-MP) Anaphylaxis (IFX) |
| 9 | 31/F | 268 (23) | 10 SB/C/A | Anorectal fever | Sig rsx SB rsx Div colost | yes | CCS, MES, AZA, MNZ, CPX, IFX, TPN | Allergy (MNZ) |
| 10 | 37/M | 298 (22) | 6 A/C | Perianal fever | None | no | CCS, MES, MTX, 6-MP, IFX, CPX, MNZ | None |
| 11 | 16/M | 256 (23) | 1.5 SB/C | Enterocut fever | None | yes | CCS, MES, 6-MP, CPX, IFX. TPN | None |
| 12 | 27/M | 298 (29) | 14 A/C/SB | Enterocut fever | Cecal rsx Ileostomy Standard colectomy | yes | CCS, MES, AZA, 6-MP, MTZ, IFX, TCL | None |
| 13 | 25/F | 207 (20) | 12 SB/C | None | Ileectomy Proctectomy | yes | CCS, AZA, SFD, MES, CSA, IFX | Tremor and mental status change (CSA) |
| 14 | 18/F | 210 (29) | 12 A/SB/C | Perianal | None | yes | CCS, AZA, MTX, 6-MP, TCL, MES, MNZ, IFX, NTL | Pancreatitis (AZA) Anaphylaxis (IFX) Renal failure (TCL) |
| 15 | 28/M | 264 (22) | 10 SB/C | No | Ileal rsx (3) | yes | CCS, MES, AZA, 6-MP, MTX, MNZ, CPX, CSA, IFX | None |
| 16 | 27/F | 199 (18) | 8 C/A | Perianal rectovaginal | Partial colectomy Total colectomy | yes | CCS, MES, 6-MP, AZA, MTX, MNZ, MTX, CSA, IFX | Steroid-induced psychosis |
| 17 | 16/M | 233 (24) | 8 A/C/SB | Perianal | None | Yes | CCS, MES, 6-MP, AZA, CYC, MNZ, CPX, THA, MTX, IFX, ADL, TPN | Neutropenia (6-MP) Liver toxicity (CSA) Arrythmia and anaphylaxis (IFX) Peripheral neuropathy (THA) |
| 18 | 24/F | 191 (17) | 6 Duod/C | None | None | Yes | CCS, MES, 6-MP, AZA, MTX, THA, CPX, MNZ, IFX | Anaphylaxis (IFX) Mental status change (CCS and MNZ) Seizures (CPX) |
| 19 | 21/M | 101 (23) | 6 C/A | Enterovesical Perianal | None | No | CCS, MES, 6-MP, AZA, MNZ, IFX | Anaphylaxis (IFX) Pancreatitis (6-MP) |
| 20 | 29/M | 228 (21) | 9 Ileal/C/A | Perirectal | Div colost Ileocolonic rsx | Yes | CCS, AZA, IFX, CPX, MNZ | None |
| 21 | 42/F | 91 (17) | 8 C/SB | None | Proctocolectomy SB rsx (3) | Yes | CCS, MES, 6-MP, MMF, AZA, MTX, CPX, MNZ, IFX, ADL | Petechiae (6-MP) Serum sickness (IFX) Fever and vomiting (AZA) |
| 22 | 52/M | 168 (20) | 27 SB/C | None | SB rsx (4) | Yes | CCS, MES, CPX, MNZ 6-MP, AZA, MTX, IFX, ADL | Anaphylaxis (IFX)Flu-like symptoms (ADL) |
| 23 | 25/F | 237 (24) | 8 C/A | Perianal fever | Fistulae | Yes | CCS, MES, MNZ, CPX, AZA, 6-MP, MTX, IFX, ADL | Edema (MES) Breathing problems (IFX) Peripheral neuropathy (MNZ) |
| 24 | 31/F | 181 (19) | 17 A/SB/C | Perianal rectovaginal (SB stx, Rectal stx) | Ileostomy Partial colectomy X2 SB rsx X2 | Yes | CCS, AZA, CSA, IFX, ADL, MNZ, TPN | Sepsis (IFX) |
A indicates anal; C, colon; enterocut, enterocutaneous; duod, duodenum; SB, small bowel; rsx, resection; Sig, sigmoid; IC, ileocecal; Div colost, diverting colostomy; stx, stricture; ADL, adalimumab; AZA, azathioprine; CCS, corticosteroids; CPX, ciprofloxacin; CSA, cyclosporine; CYC, cyclophosphamide; ETN, etanercept; IFX, infliximab; 6-MP, 6-mercaptopurine; MES, mesalazine; MMF, micophenolato-mofetil; MNZ, metronidazole; MTX-methotrexate; NTL, natalizumab; SFD, sulfadiazine; TCL, tacrolimus; and THA, thalidomide; and TPN, total parenteral nutrition.