Copies of HTLV-1 integrase DNA in blood and tissues/106 cells in the infected macaques
. | PBMC . | LN . | BM . | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Weeks after inoculation . | Weeks after inoculation . | Weeks after inoculation . | ||||||||
−4 . | 2 . | 4 . | 8 . | 10 . | 12 . | 14 . | 12 . | 46 . | 46 . | |
p12KO | ||||||||||
P065 | — | — | — | — | — | — | — | — | — | — |
P067 | — | — | — | 45 | — | — | — | — | — | — |
M903 | — | — | — | — | — | — | 14 | — | — | — |
M045 | — | — | — | — | — | — | — | — | — | — |
p30KO | ||||||||||
P063 | — | — | — | — | — | — | — | — | — | — |
P064 | — | — | — | — | — | — | 13 | — | — | 44 |
P011 | — | — | — | — | 25 | 87 | — | — | — | — |
M901 | — | — | — | — | — | 22 | — | — | — | — |
pHBZKO | ||||||||||
P068 | — | — | — | — | — | 25 | — | — | — | 42 |
P069 | — | 16 | 49 | 93 | 91 | 116 | 38 | 27.35 | — | — |
M900 | — | — | — | — | — | 11 | — | — | — | — |
M902 | — | — | — | — | — | 40 | — | — | — | — |
Controls | ||||||||||
P062 | — | — | — | — | — | — | — | — | — | — |
M895 | — | — | — | — | — | — | — | — | — | — |
. | PBMC . | LN . | BM . | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Weeks after inoculation . | Weeks after inoculation . | Weeks after inoculation . | ||||||||
−4 . | 2 . | 4 . | 8 . | 10 . | 12 . | 14 . | 12 . | 46 . | 46 . | |
p12KO | ||||||||||
P065 | — | — | — | — | — | — | — | — | — | — |
P067 | — | — | — | 45 | — | — | — | — | — | — |
M903 | — | — | — | — | — | — | 14 | — | — | — |
M045 | — | — | — | — | — | — | — | — | — | — |
p30KO | ||||||||||
P063 | — | — | — | — | — | — | — | — | — | — |
P064 | — | — | — | — | — | — | 13 | — | — | 44 |
P011 | — | — | — | — | 25 | 87 | — | — | — | — |
M901 | — | — | — | — | — | 22 | — | — | — | — |
pHBZKO | ||||||||||
P068 | — | — | — | — | — | 25 | — | — | — | 42 |
P069 | — | 16 | 49 | 93 | 91 | 116 | 38 | 27.35 | — | — |
M900 | — | — | — | — | — | 11 | — | — | — | — |
M902 | — | — | — | — | — | 40 | — | — | — | — |
Controls | ||||||||||
P062 | — | — | — | — | — | — | — | — | — | — |
M895 | — | — | — | — | — | — | — | — | — | — |
LN indicates lymph node; BM, bone marrow; and —, viral DNA not detectable.