Poor prognostic factors in CLL
| Advanced stage at diagnosis |
| Advanced age |
| Male sex |
| Diffuse pattern of bone marrow infiltration |
| Short lymphocyte doubling time |
| High expression of Ki67, p27 |
| High serum levels of β2-microglobulin, thymidine kinase, soluble CD23, and TNFα |
| Poor-risk cytogenetics: 17p, 11q deletions, and complex cytogenetic abnormalities |
| IgVH unmutated mutational status |
| High level of CD38 expression |
| High level of ZAP70 expression |
| High level of expression of lipoprotein lipase |
| Altered microRNA expression |
| Poor response to therapy or short duration of response |
| Advanced stage at diagnosis |
| Advanced age |
| Male sex |
| Diffuse pattern of bone marrow infiltration |
| Short lymphocyte doubling time |
| High expression of Ki67, p27 |
| High serum levels of β2-microglobulin, thymidine kinase, soluble CD23, and TNFα |
| Poor-risk cytogenetics: 17p, 11q deletions, and complex cytogenetic abnormalities |
| IgVH unmutated mutational status |
| High level of CD38 expression |
| High level of ZAP70 expression |
| High level of expression of lipoprotein lipase |
| Altered microRNA expression |
| Poor response to therapy or short duration of response |
TNFα indicates tumor necrosis factor α.