Criteria for response to therapy in CLL
| Response level/criteria . |
|---|
| CR |
| Absence of clonal lymphocytosis |
| Absence of significant lymphadenopathy |
| No hepatosplenomegaly by physical examination |
| Absence of constitutional symptoms |
| Neutrophils ≥ 1500/μL |
| Platelets > 100 000/μL |
| Hemoglobin > 11.0 g/dL untransfused |
| BM free of clonal lymphocytes (in clinical trials only) |
| CRi |
| As for CR, but with persistent anemia, thrombocytopenia, or neutropenia |
| PR |
| Decrease of ≥ 50% in the number of blood lymphocytes |
| Decrease of ≥ 50% in lymph node size in the sum products of up to 6 lymph nodes, no increase in any lymph node, and no new enlarged lymph nodes |
| Decrease of ≥ 50% in the size of hepatosplenomegaly |
| One of the following: |
| Neutrophils ≥ 1500/μL or > 50% improvement from baseline |
| Platelets > 100 000/μL or > 50% improvement from baseline |
| Hemoglobin > 11.0 g/dL or > 50% improvement from baseline |
| Response level/criteria . |
|---|
| CR |
| Absence of clonal lymphocytosis |
| Absence of significant lymphadenopathy |
| No hepatosplenomegaly by physical examination |
| Absence of constitutional symptoms |
| Neutrophils ≥ 1500/μL |
| Platelets > 100 000/μL |
| Hemoglobin > 11.0 g/dL untransfused |
| BM free of clonal lymphocytes (in clinical trials only) |
| CRi |
| As for CR, but with persistent anemia, thrombocytopenia, or neutropenia |
| PR |
| Decrease of ≥ 50% in the number of blood lymphocytes |
| Decrease of ≥ 50% in lymph node size in the sum products of up to 6 lymph nodes, no increase in any lymph node, and no new enlarged lymph nodes |
| Decrease of ≥ 50% in the size of hepatosplenomegaly |
| One of the following: |
| Neutrophils ≥ 1500/μL or > 50% improvement from baseline |
| Platelets > 100 000/μL or > 50% improvement from baseline |
| Hemoglobin > 11.0 g/dL or > 50% improvement from baseline |
CR indicates complete response; CRi, CR with incomplete marrow recovery; and PR, partial response.