Estimated PK parameters of rituximab for patients stratified by FCGR2A (A) and FCGR3A (B) genotypes
| PK parameter . | Cycle no./dose, mg/m2 . | FCGR2A . | FCGR3A . | ||||
|---|---|---|---|---|---|---|---|
| HH (n = 5) . | HR (n = 10) . | RR (n = 4) . | FV (n = 9) . | FF (n = 9) . | VV (n = 1) . | ||
| Cmax, μg/mL | 1/375 | ||||||
| Mean (n) | 134 (5) | 182 (10) | 213 (4) | 178 (9) | 178 (9) | 138 | |
| SD | 26 | 104 | 20 | 65 | 101 | ||
| CV% | 20 | 57 | 9 | 36 | 57 | ||
| P | .11 | N/A | |||||
| AUC0-last, μg/mL | |||||||
| Mean (n) | 9930 (5) | 15 790 (10) | 25 202 (4) | 13 249 (9) | 20 580 (9) | 3900 | |
| SD | 6860 | 8436 | 13 256 | 6093 | 12 140 | ||
| CV% | 69 | 53 | 53 | 46 | 59 | ||
| P | .22 | N/A | |||||
| Cmax, μg/mL | 3/500 | ||||||
| Mean (n) | 219 (4) | 272 (9) | 353 (4) | 266 (8) | 302 (8) | 189 | |
| SD | 68 | 113 | 84 | 119 | 101 | ||
| CV% | 31 | 41 | 24 | 42 | 34 | ||
| P | .19 | N/A | |||||
| AUC0-last, μg/mL | |||||||
| Mean (n) | 44 308 (4) | 63 208 (9) | 81 220 (4) | 49 225 (8) | 77 226 (8) | 59 382 | |
| SD | 22 781 | 46 595 | 13 712 | 19 497 | 48 410 | ||
| CV% | 51 | 74 | 17 | 40 | 63 | ||
| P | .35 | N/A | |||||
| Cmax, μg/mL | 6/500 | ||||||
| Mean (n) | 267 (3) | 447 (8) | 417 (3) | 424 (7) | 402 (7) | 247 | |
| SD | 69 | 242 | 167 | 213 | 222 | ||
| CV% | 26 | 54 | 40 | 50 | 55 | ||
| P | .29 | N/A | |||||
| AUC0-last, μg/mL | |||||||
| Mean (n) | 84 102 (3) | 97 407 (8) | 93 456 (3) | 93 772 (7) | 92 350 (7) | 101 423 | |
| SD | 33 000 | 69 574 | 56 194 | 56 976 | 68 140 | ||
| CV% | 39 | 71 | 60 | 61 | 74 | ||
| P | .77 | N/A | |||||
| t, d | |||||||
| Mean (n) | 33.3 (3) | 32 (8) | 33.2 (3) | 34.3 (7) | 29.2 (7) | 39.8 | |
| SD | 16.8 | 15.3 | 4.7 | 15.1 | 12.2 | ||
| CV% | 50 | 48 | 14 | 44 | 42 | ||
| P | .77 | N/A | |||||
| PK parameter . | Cycle no./dose, mg/m2 . | FCGR2A . | FCGR3A . | ||||
|---|---|---|---|---|---|---|---|
| HH (n = 5) . | HR (n = 10) . | RR (n = 4) . | FV (n = 9) . | FF (n = 9) . | VV (n = 1) . | ||
| Cmax, μg/mL | 1/375 | ||||||
| Mean (n) | 134 (5) | 182 (10) | 213 (4) | 178 (9) | 178 (9) | 138 | |
| SD | 26 | 104 | 20 | 65 | 101 | ||
| CV% | 20 | 57 | 9 | 36 | 57 | ||
| P | .11 | N/A | |||||
| AUC0-last, μg/mL | |||||||
| Mean (n) | 9930 (5) | 15 790 (10) | 25 202 (4) | 13 249 (9) | 20 580 (9) | 3900 | |
| SD | 6860 | 8436 | 13 256 | 6093 | 12 140 | ||
| CV% | 69 | 53 | 53 | 46 | 59 | ||
| P | .22 | N/A | |||||
| Cmax, μg/mL | 3/500 | ||||||
| Mean (n) | 219 (4) | 272 (9) | 353 (4) | 266 (8) | 302 (8) | 189 | |
| SD | 68 | 113 | 84 | 119 | 101 | ||
| CV% | 31 | 41 | 24 | 42 | 34 | ||
| P | .19 | N/A | |||||
| AUC0-last, μg/mL | |||||||
| Mean (n) | 44 308 (4) | 63 208 (9) | 81 220 (4) | 49 225 (8) | 77 226 (8) | 59 382 | |
| SD | 22 781 | 46 595 | 13 712 | 19 497 | 48 410 | ||
| CV% | 51 | 74 | 17 | 40 | 63 | ||
| P | .35 | N/A | |||||
| Cmax, μg/mL | 6/500 | ||||||
| Mean (n) | 267 (3) | 447 (8) | 417 (3) | 424 (7) | 402 (7) | 247 | |
| SD | 69 | 242 | 167 | 213 | 222 | ||
| CV% | 26 | 54 | 40 | 50 | 55 | ||
| P | .29 | N/A | |||||
| AUC0-last, μg/mL | |||||||
| Mean (n) | 84 102 (3) | 97 407 (8) | 93 456 (3) | 93 772 (7) | 92 350 (7) | 101 423 | |
| SD | 33 000 | 69 574 | 56 194 | 56 976 | 68 140 | ||
| CV% | 39 | 71 | 60 | 61 | 74 | ||
| P | .77 | N/A | |||||
| t, d | |||||||
| Mean (n) | 33.3 (3) | 32 (8) | 33.2 (3) | 34.3 (7) | 29.2 (7) | 39.8 | |
| SD | 16.8 | 15.3 | 4.7 | 15.1 | 12.2 | ||
| CV% | 50 | 48 | 14 | 44 | 42 | ||
| P | .77 | N/A | |||||