Patient outcomes (PFS, OS, and ORR) in relation to known prognostic factors
| Factor . | FC . | R-FC . | ||||||
|---|---|---|---|---|---|---|---|---|
| n . | PFS hazard ratio (95% CI), P . | OS hazard ratio (95% CI), P . | ORR % (P) . | n . | PFS hazard ratio (95% CI), P . | OS hazard ratio (95% CI), P . | ORR % (P) . | |
| Age ≥ 65 y vs < 65 y | 209 (90 vs 119) | 1.03 (0.72-1.48), .87 | 0.92 (0.51-1.64), .77 | 49 vs 65 (.024) | 210 (88 vs 122) | 2.1 (1.43-3.11), .00018 | 4.71 (2.43-9.12), 4.6e-06 | 62 vs 73 (.13) |
| Binet stage C vs A/B | 209 (68 vs 141) | 2.03 (1.4-2.93), .00018 | 2.01 (1.13-3.57), .018 | 41 vs 66 (.00095) | 210 (64 vs 146) | 1.67 (1.12-2.49), .011 | 1.37 (0.74-2.52), .32 | 55 vs 75 (.0059) |
| IgVH unmutated vs mutated | 208 (133 vs 75) | 2.03 (1.35-3.06), .00072 | 2.47 (1.23-4.97), .011 | 53 vs 65 (.11) | 202 (123 vs 79) | 1.98 (1.28-3.07), .0021 | 2.14 (1.08-4.27), .03 | 63 vs 77 (.044) |
| CD38+ vs CD38− | 133 (62 vs 71) | 1.47 (0.91-2.35), .11 | 1.9 (0.9-4.01), .092 | 55 vs 63 (.38) | 134 (70 vs 64) | 0.84 (0.51-1.38), .49 | 0.96 (0.49-1.88), .9 | 64 vs 66 (1) |
| ZAP70+ vs ZAP70− | 179 (99 vs 80) | 1.92 (1.28-2.88), .0017 | 2.13 (1.06-4.27), .034 | 47 vs 69 (.0061) | 189 (103 vs 86) | 1.97 (1.25-3.1), .0037 | 1.5 (0.76-2.95), .24 | 65 vs 72 (.35) |
| Del17p yes vs no | 206 (20 vs 186) | 2.48 (1.46-4.21), .00075 | 3.05 (1.47-6.32), .0027 | 15 vs 63 (5.1e-05) | 209 (15 vs 194) | 3.24 (1.74-6.03), .00021 | 3.02 (1.33-6.85), .0082 | 33 vs 71 (.0067) |
| Del11q yes vs no | 206 (47 vs 159) | 1.52 (1.02, 2.27), .039 | 1.35 (0.72-2.53), .34 | 53 vs 60 (.5) | 210 (39 vs 171) | 0.86 (0.51-1.45), .58 | 1.11 (0.53-2.31), .78 | 62 vs 70 (.34) |
| Del13q yes vs no | 208 (124 vs 84) | 1.1 (.76-1.59), .62 | 1.11 (0.61-2.01), .74 | 59 vs 56 (.77) | 210 (117 vs 93) | 0.96 (0.65-1.42), .83 | 1.03 (0.57-1.87), .92 | 72 vs 65 (.3) |
| Trisomy12 yes vs no | 206 (33 vs 173) | 1.31 (0.8-2.14), .28 | 0.74 (0.29-1.88), .53 | 52 vs 60 (.44) | 210 (24 vs 186) | 1.13 (0.62-2.07), .69 | 1.28 (0.54-3.04), .57 | 62 vs 69 (.49) |
| Factor . | FC . | R-FC . | ||||||
|---|---|---|---|---|---|---|---|---|
| n . | PFS hazard ratio (95% CI), P . | OS hazard ratio (95% CI), P . | ORR % (P) . | n . | PFS hazard ratio (95% CI), P . | OS hazard ratio (95% CI), P . | ORR % (P) . | |
| Age ≥ 65 y vs < 65 y | 209 (90 vs 119) | 1.03 (0.72-1.48), .87 | 0.92 (0.51-1.64), .77 | 49 vs 65 (.024) | 210 (88 vs 122) | 2.1 (1.43-3.11), .00018 | 4.71 (2.43-9.12), 4.6e-06 | 62 vs 73 (.13) |
| Binet stage C vs A/B | 209 (68 vs 141) | 2.03 (1.4-2.93), .00018 | 2.01 (1.13-3.57), .018 | 41 vs 66 (.00095) | 210 (64 vs 146) | 1.67 (1.12-2.49), .011 | 1.37 (0.74-2.52), .32 | 55 vs 75 (.0059) |
| IgVH unmutated vs mutated | 208 (133 vs 75) | 2.03 (1.35-3.06), .00072 | 2.47 (1.23-4.97), .011 | 53 vs 65 (.11) | 202 (123 vs 79) | 1.98 (1.28-3.07), .0021 | 2.14 (1.08-4.27), .03 | 63 vs 77 (.044) |
| CD38+ vs CD38− | 133 (62 vs 71) | 1.47 (0.91-2.35), .11 | 1.9 (0.9-4.01), .092 | 55 vs 63 (.38) | 134 (70 vs 64) | 0.84 (0.51-1.38), .49 | 0.96 (0.49-1.88), .9 | 64 vs 66 (1) |
| ZAP70+ vs ZAP70− | 179 (99 vs 80) | 1.92 (1.28-2.88), .0017 | 2.13 (1.06-4.27), .034 | 47 vs 69 (.0061) | 189 (103 vs 86) | 1.97 (1.25-3.1), .0037 | 1.5 (0.76-2.95), .24 | 65 vs 72 (.35) |
| Del17p yes vs no | 206 (20 vs 186) | 2.48 (1.46-4.21), .00075 | 3.05 (1.47-6.32), .0027 | 15 vs 63 (5.1e-05) | 209 (15 vs 194) | 3.24 (1.74-6.03), .00021 | 3.02 (1.33-6.85), .0082 | 33 vs 71 (.0067) |
| Del11q yes vs no | 206 (47 vs 159) | 1.52 (1.02, 2.27), .039 | 1.35 (0.72-2.53), .34 | 53 vs 60 (.5) | 210 (39 vs 171) | 0.86 (0.51-1.45), .58 | 1.11 (0.53-2.31), .78 | 62 vs 70 (.34) |
| Del13q yes vs no | 208 (124 vs 84) | 1.1 (.76-1.59), .62 | 1.11 (0.61-2.01), .74 | 59 vs 56 (.77) | 210 (117 vs 93) | 0.96 (0.65-1.42), .83 | 1.03 (0.57-1.87), .92 | 72 vs 65 (.3) |
| Trisomy12 yes vs no | 206 (33 vs 173) | 1.31 (0.8-2.14), .28 | 0.74 (0.29-1.88), .53 | 52 vs 60 (.44) | 210 (24 vs 186) | 1.13 (0.62-2.07), .69 | 1.28 (0.54-3.04), .57 | 62 vs 69 (.49) |