Patient data including clinical stage at time of experiment, FISH results, mutational status, VH gene usage, ZAP-70 results, and assays performed with this sample
| Patient ID . | Clinical stage at time of experiment . | FISH results . | Mutational status . | VH gene usage . | ZAP-70 results . | Assays performed . |
|---|---|---|---|---|---|---|
| Viable cells | ||||||
| CLL 1 | C | normal | UM | V3-23 | pos | ELISA |
| CLL 8 | B | 13q− | M | V1-81 | nd | ELISA |
| CLL 16 | A | 13q− | UM | V1-69 | neg | Cell survival |
| CLL 23 | A | normal | UM | V1-02 | nd | ELISA |
| CLL 46 | B | 11q−, 13q−, 14q− | UM | V1-69 | neg | qRT-PCR |
| CLL 47 | A | 13q− | M | V3-23 | neg | qRT-PCR |
| CLL 48 | A | 13q− | M | V1-18 | neg | qRT-PCR |
| CLL 55 | A | 13q−, 14q− | M | V4-59 | neg | Cell survival |
| CLL 56 | B | 13q− | M | V1-08 | neg | Cell survival |
| CLL 62 | A | 13q− | M | V3-15 | neg | Cell survival |
| CLL 64 | B | 13q− | M | V1-69 | neg | Cell survival |
| CLL 66 | A | 13q− | M | V4-39 | neg | Cell survival |
| CLL 67 | A | 13q− | M | V1-18 | neg | Cell survival; qRT-PCR; ELISA |
| CLL 69 | A | 13q− | M | V1-08 | neg | Cell survival; NFκB activity |
| CLL 70 | B | 13q− | M | V3-53 | neg | Cell survival |
| CLL 71 | B | 11q−, 13q−, 14q− | UM | V1-69 | neg | Cell survival |
| CLL 72 | C | 13q− | M | V4-34 | neg | Cell survival |
| CLL 74 | A | 13q− | UM | V1-69 | neg | Cell survival |
| CLL 77 | A | 13q− | M | V3-23 | neg | Cell survival |
| CLL 78 | A | 13q− | M | V1-18 | neg | Cell survival |
| CLL 79 | B | 13q− | M | V3-53 | neg | Cell survival |
| CLL 80 | B | 11q−, 13q−, 14q− | UM | V1-69 | neg | Cell survival; NFκB activity |
| CLL 82 | A | normal | UM | V3-33 | pos | qRT-PCR |
| CLL 83 | B | 13q− | M | V1-69 | neg | NFκB activity |
| CLL 84 | C | 13q− | M | V3-21 | neg | Cell survival |
| CLL 85 | A | 13q− | M | V3-15 | neg | ELISA; NFκB activity |
| CLL 89 | A | 13q− | M | V3-23 | neg | Cell survival; ELISA |
| CLL 92 | A | 13q− | M | V3-23 | nd | Cell survival |
| CLL 93 | B | 13q− | M | V3-53 | neg | NFκB activity |
| Serum | ||||||
| CLL S1 | A | normal | M | V4-61 | nd | CD14 ELISA |
| CLL S2 | A | t(6;12), 13q− | M | V4-59 | nd | CD14 ELISA |
| CLL S3 | A | 13q− | M | V4-59 | neg | CD14 ELISA |
| CLL S4 | A | 13q− | M | V3-23 | neg | CD14 ELISA |
| CLL S5 | A | normal | M | V3-53 | neg | CD14 ELISA |
| CLL S6 | A | normal | UM | V1-69 | pos | CD14 ELISA |
| CLL S7 | A | normal | UM | V4-59 | pos | CD14 ELISA |
| CLL S8 | nd | normal | UM | V3-48 | nd | CD14 ELISA |
| CLL S9 | C | normal | UM | V3-23 | neg | CD14 ELISA |
| CLL S10 | B | 13q−, 11q− | UM | V1-69 | nd | CD14 ELISA |
| CLL S11 | A | 13q− | M | V3-72 | nd | CD14 ELISA |
| CLL S12 | nd | 13q− | UM | V3-30 | pos | CD14 ELISA |
| CLL S13 | A | 13q− | M | V3-21 | neg | CD14 ELISA |
| CLL S14 | A | 11q−, 13q− | UM | nd | nd | CD14 ELISA |
| CLL S15 | A | normal | M | V4-30.4 | neg | CD14 ELISA |
| CLL S16 | A | normal | M | V4-34 | nd | CD14 ELISA |
| CLL S17 | A | normal | M | V1-08 | nd | CD14 ELISA |
| CLL S18 | nd | normal | M | nd | nd | CD14 ELISA |
| CLL S19 | A | 13q− | M | V3-34 | nd | CD14 ELISA |
| CLL S20 | A | 11q−, 13q− | M | V3-21 | neg | CD14 ELISA |
| CLL S21 | A | normal | M | V3-66 | neg | CD14 ELISA |
| Patient ID . | Clinical stage at time of experiment . | FISH results . | Mutational status . | VH gene usage . | ZAP-70 results . | Assays performed . |
|---|---|---|---|---|---|---|
| Viable cells | ||||||
| CLL 1 | C | normal | UM | V3-23 | pos | ELISA |
| CLL 8 | B | 13q− | M | V1-81 | nd | ELISA |
| CLL 16 | A | 13q− | UM | V1-69 | neg | Cell survival |
| CLL 23 | A | normal | UM | V1-02 | nd | ELISA |
| CLL 46 | B | 11q−, 13q−, 14q− | UM | V1-69 | neg | qRT-PCR |
| CLL 47 | A | 13q− | M | V3-23 | neg | qRT-PCR |
| CLL 48 | A | 13q− | M | V1-18 | neg | qRT-PCR |
| CLL 55 | A | 13q−, 14q− | M | V4-59 | neg | Cell survival |
| CLL 56 | B | 13q− | M | V1-08 | neg | Cell survival |
| CLL 62 | A | 13q− | M | V3-15 | neg | Cell survival |
| CLL 64 | B | 13q− | M | V1-69 | neg | Cell survival |
| CLL 66 | A | 13q− | M | V4-39 | neg | Cell survival |
| CLL 67 | A | 13q− | M | V1-18 | neg | Cell survival; qRT-PCR; ELISA |
| CLL 69 | A | 13q− | M | V1-08 | neg | Cell survival; NFκB activity |
| CLL 70 | B | 13q− | M | V3-53 | neg | Cell survival |
| CLL 71 | B | 11q−, 13q−, 14q− | UM | V1-69 | neg | Cell survival |
| CLL 72 | C | 13q− | M | V4-34 | neg | Cell survival |
| CLL 74 | A | 13q− | UM | V1-69 | neg | Cell survival |
| CLL 77 | A | 13q− | M | V3-23 | neg | Cell survival |
| CLL 78 | A | 13q− | M | V1-18 | neg | Cell survival |
| CLL 79 | B | 13q− | M | V3-53 | neg | Cell survival |
| CLL 80 | B | 11q−, 13q−, 14q− | UM | V1-69 | neg | Cell survival; NFκB activity |
| CLL 82 | A | normal | UM | V3-33 | pos | qRT-PCR |
| CLL 83 | B | 13q− | M | V1-69 | neg | NFκB activity |
| CLL 84 | C | 13q− | M | V3-21 | neg | Cell survival |
| CLL 85 | A | 13q− | M | V3-15 | neg | ELISA; NFκB activity |
| CLL 89 | A | 13q− | M | V3-23 | neg | Cell survival; ELISA |
| CLL 92 | A | 13q− | M | V3-23 | nd | Cell survival |
| CLL 93 | B | 13q− | M | V3-53 | neg | NFκB activity |
| Serum | ||||||
| CLL S1 | A | normal | M | V4-61 | nd | CD14 ELISA |
| CLL S2 | A | t(6;12), 13q− | M | V4-59 | nd | CD14 ELISA |
| CLL S3 | A | 13q− | M | V4-59 | neg | CD14 ELISA |
| CLL S4 | A | 13q− | M | V3-23 | neg | CD14 ELISA |
| CLL S5 | A | normal | M | V3-53 | neg | CD14 ELISA |
| CLL S6 | A | normal | UM | V1-69 | pos | CD14 ELISA |
| CLL S7 | A | normal | UM | V4-59 | pos | CD14 ELISA |
| CLL S8 | nd | normal | UM | V3-48 | nd | CD14 ELISA |
| CLL S9 | C | normal | UM | V3-23 | neg | CD14 ELISA |
| CLL S10 | B | 13q−, 11q− | UM | V1-69 | nd | CD14 ELISA |
| CLL S11 | A | 13q− | M | V3-72 | nd | CD14 ELISA |
| CLL S12 | nd | 13q− | UM | V3-30 | pos | CD14 ELISA |
| CLL S13 | A | 13q− | M | V3-21 | neg | CD14 ELISA |
| CLL S14 | A | 11q−, 13q− | UM | nd | nd | CD14 ELISA |
| CLL S15 | A | normal | M | V4-30.4 | neg | CD14 ELISA |
| CLL S16 | A | normal | M | V4-34 | nd | CD14 ELISA |
| CLL S17 | A | normal | M | V1-08 | nd | CD14 ELISA |
| CLL S18 | nd | normal | M | nd | nd | CD14 ELISA |
| CLL S19 | A | 13q− | M | V3-34 | nd | CD14 ELISA |
| CLL S20 | A | 11q−, 13q− | M | V3-21 | neg | CD14 ELISA |
| CLL S21 | A | normal | M | V3-66 | neg | CD14 ELISA |
FISH indicates fluorescent in situ hybridization; UM, unmutated; M, mutated; pos, positive; neg, negative; and nd, not determined.