Table 1 Kinase inhibition profile of... | American Society of Hematology

Table 1

Kinase inhibition profile of CAL-101

IC₅₀ (nM)	Fold-selectivity, PI3K
IC₅₀ (nM)	Class I			Class II	Class III	Class IV		Others
p110δ	p110α	p110β	p110γ	CIIβ	hVPS34	DNA-PK	mTOR	PIP5Ka	PIP5Kb
2.5	> 300×	> 200×	> 40×	> 400×	> 400×	> 3000 ×	> 4000 ×	> 400 ×	> 400 ×

IC₅₀ (nM)	Fold-selectivity, PI3K
IC₅₀ (nM)	Class I			Class II	Class III	Class IV		Others
p110δ	p110α	p110β	p110γ	CIIβ	hVPS34	DNA-PK	mTOR	PIP5Ka	PIP5Kb
2.5	> 300×	> 200×	> 40×	> 400×	> 400×	> 3000 ×	> 4000 ×	> 400 ×	> 400 ×

CAL-101 shows PI3K/p110δ selectivity in kinase profiling assay.