Select event-based toxicities possibly, probably, or definitely attributed to AZT combined with VCG, over a total of 137 cycles
| Toxicity . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . |
|---|---|---|---|---|
| Hematologic | ||||
| Anemia | 35 (26) | 10 (7) | 11 (8) | 5 (4) |
| Thrombocytopenia | 14 (10) | 4 (3) | 4 (3) | |
| Neutropenia | 7 (5) | 17 (12) | 17 (12) | 4 (3) |
| Bleeding | 1 (< 1) | — | — | — |
| Gastrointestinal | ||||
| Abdominal pain | 7 (5) | 1 (< 1) | — | — |
| Anorexia | 11 (8) | 7 (5) | — | — |
| Constipation | 4 (3) | — | — | — |
| Diarrhea | 9 (7) | — | — | — |
| Dysguesia | 10 (7) | — | — | — |
| Mucositis | 1 (< 1) | — | — | |
| Nausea | 15 (11) | 4 (3) | 1 (< 1) | — |
| Vomit | 5 (4) | 3 (2) | — | — |
| Major infection/neutropenic fever | — | 1 (< 1) | 3 (2) | — |
| Metabolic | ||||
| Elevated alkaline phosphatase | 7 (5) | — | — | — |
| Elevated amylase | 5 (4) | — | — | — |
| Elevated transaminases | 8 (6) | 1 (< 1) | — | — |
| Elevated bilirubin | — | 1 (< 1) | — | — |
| Elevated CPK | 2 (1) | — | — | — |
| Neurologic | ||||
| Headache | 5 (4) | 2 (1) | — | — |
| Neuropathy | 5 (4) | 2 (1) | — | — |
| Insomnia | 2 (1) | — | 1 (< 1) | — |
| Toxicity . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . |
|---|---|---|---|---|
| Hematologic | ||||
| Anemia | 35 (26) | 10 (7) | 11 (8) | 5 (4) |
| Thrombocytopenia | 14 (10) | 4 (3) | 4 (3) | |
| Neutropenia | 7 (5) | 17 (12) | 17 (12) | 4 (3) |
| Bleeding | 1 (< 1) | — | — | — |
| Gastrointestinal | ||||
| Abdominal pain | 7 (5) | 1 (< 1) | — | — |
| Anorexia | 11 (8) | 7 (5) | — | — |
| Constipation | 4 (3) | — | — | — |
| Diarrhea | 9 (7) | — | — | — |
| Dysguesia | 10 (7) | — | — | — |
| Mucositis | 1 (< 1) | — | — | |
| Nausea | 15 (11) | 4 (3) | 1 (< 1) | — |
| Vomit | 5 (4) | 3 (2) | — | — |
| Major infection/neutropenic fever | — | 1 (< 1) | 3 (2) | — |
| Metabolic | ||||
| Elevated alkaline phosphatase | 7 (5) | — | — | — |
| Elevated amylase | 5 (4) | — | — | — |
| Elevated transaminases | 8 (6) | 1 (< 1) | — | — |
| Elevated bilirubin | — | 1 (< 1) | — | — |
| Elevated CPK | 2 (1) | — | — | — |
| Neurologic | ||||
| Headache | 5 (4) | 2 (1) | — | — |
| Neuropathy | 5 (4) | 2 (1) | — | — |
| Insomnia | 2 (1) | — | 1 (< 1) | — |
Values are no. (%).
— indicates none observed.