Table 1

Characteristics of the patients at the time of diagnosis

No. of documented patientsNo. or mean ± SD% or range
Clinical cofactors    
    Sex: male 65 40 66 
    Age, y 54 68.1 ± 17.0 25-92 
    Preexisting conditions: cancer* 55 11 20 
    Survival at 12 mo 52 36 69.2 
Standard biologic cofactors    
    FVIII activity in plasma, % 51 6.0 ± 10.9 0-59 
    Inhibitory titer toward FVIII, BU/mL 65 66.9 ± 148.6 1-1050 
    FIX activity in plasma, % 18 117.5 ± 55.3 64-268 
    aPTT (measured/physiologic value) 37 2.4 ± 0.7 1.3-4.2 
No. of documented patientsNo. or mean ± SD% or range
Clinical cofactors    
    Sex: male 65 40 66 
    Age, y 54 68.1 ± 17.0 25-92 
    Preexisting conditions: cancer* 55 11 20 
    Survival at 12 mo 52 36 69.2 
Standard biologic cofactors    
    FVIII activity in plasma, % 51 6.0 ± 10.9 0-59 
    Inhibitory titer toward FVIII, BU/mL 65 66.9 ± 148.6 1-1050 
    FIX activity in plasma, % 18 117.5 ± 55.3 64-268 
    aPTT (measured/physiologic value) 37 2.4 ± 0.7 1.3-4.2 

aPTT indicates activated partial thromboplastin time.

*

Other preexisting conditions were allergic drug reactions (5), autoimmune disorders (4), dermatologic disorders (3), diabetes (1), postpartum (2), and idiopathic (14).

Inhibitory titers were assessed using the modified Bethesda assay.

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