Table 2

Chemotherapeutic agents active in hematologic malignancies included in the 2011 World Health Organization Model Lists of Essential Medicines

MedicineYear of FDA licensureFDA hematologic malignancy indicationsOther clinical usesDoseAWP (US dollars)*AWP per dose (US dollars)†
Asparaginase 1978 ALL AML 6000 units/m2 IV 0.007/unit 84 
Bleomycin 1973 HL, NHL  10 units/m2 IV 3.406/unit 68 
Carboplatin 1989  HL, NHL AUC 5 IV 0.407/mg 325 
Chlorambucil 1957 CLL, HL, NHL  0.4 mg/kg PO 1.141/mg 37 
Cyclophosphamide 1959 ALL, AML, CLL, CML, HL, NHL, MM  750 mg/m2 IV 0.050/mg 75 
Cytarabine 1969 ALL, AML, CML HL, NHL 2000 mg/m2 IV 0.029/mg 114 
Dacarbazine 1975 HL  375 mg/m2 IV 0.106/mg 80 
Daunorubicin 1987 ALL, AML CML, NHL 45 mg/m2 IV 4.515/mg 406 
Doxorubicin 1974 ALL, AML, CLL, HL, NHL, MM  60 mg/m2 IV 1.108/mg 133 
Etoposide 1983  ALL, AML, HL, NHL, MM 50 mg/m2 IV 0.585/mg 58 
Fluorouracil 1962  ALL 15 mg/kg IV 0.010/mg 12 
Hydroxyurea 1967 CML AML, ALL, NHL 30 mg/kg PO 0.003/mg 8 
Ifosfamide 1988  ALL, HL, NHL, MM 5000 mg/m2 IV 0.056/mg 563 
Mercaptopurine 1953 ALL AML, CML, NHL 2.5 mg/kg PO 0.072/mg 14 
Methotrexate 1959 ALL, NHL AML, HL 1000 mg/m2 IV 0.154/mg 308 
Paclitaxel 1992  NHL, MM 175 mg/m2 IV 0.964/mg 337 
Procarbazine 1969 HL NHL, MM 100 mg/m2 PO 1.114/mg 223 
Thioguanine 1966 AML  2 mg/kg PO 0.262/mg 42 
Vinblastine 1965 HL, NHL  6 mg/m2 IV 2.738/mg 33 
Vincristine 1963 ALL, HL, NHL CLL, MM 1.4 mg/m2 IV 13.090/mg 26 
MedicineYear of FDA licensureFDA hematologic malignancy indicationsOther clinical usesDoseAWP (US dollars)*AWP per dose (US dollars)†
Asparaginase 1978 ALL AML 6000 units/m2 IV 0.007/unit 84 
Bleomycin 1973 HL, NHL  10 units/m2 IV 3.406/unit 68 
Carboplatin 1989  HL, NHL AUC 5 IV 0.407/mg 325 
Chlorambucil 1957 CLL, HL, NHL  0.4 mg/kg PO 1.141/mg 37 
Cyclophosphamide 1959 ALL, AML, CLL, CML, HL, NHL, MM  750 mg/m2 IV 0.050/mg 75 
Cytarabine 1969 ALL, AML, CML HL, NHL 2000 mg/m2 IV 0.029/mg 114 
Dacarbazine 1975 HL  375 mg/m2 IV 0.106/mg 80 
Daunorubicin 1987 ALL, AML CML, NHL 45 mg/m2 IV 4.515/mg 406 
Doxorubicin 1974 ALL, AML, CLL, HL, NHL, MM  60 mg/m2 IV 1.108/mg 133 
Etoposide 1983  ALL, AML, HL, NHL, MM 50 mg/m2 IV 0.585/mg 58 
Fluorouracil 1962  ALL 15 mg/kg IV 0.010/mg 12 
Hydroxyurea 1967 CML AML, ALL, NHL 30 mg/kg PO 0.003/mg 8 
Ifosfamide 1988  ALL, HL, NHL, MM 5000 mg/m2 IV 0.056/mg 563 
Mercaptopurine 1953 ALL AML, CML, NHL 2.5 mg/kg PO 0.072/mg 14 
Methotrexate 1959 ALL, NHL AML, HL 1000 mg/m2 IV 0.154/mg 308 
Paclitaxel 1992  NHL, MM 175 mg/m2 IV 0.964/mg 337 
Procarbazine 1969 HL NHL, MM 100 mg/m2 PO 1.114/mg 223 
Thioguanine 1966 AML  2 mg/kg PO 0.262/mg 42 
Vinblastine 1965 HL, NHL  6 mg/m2 IV 2.738/mg 33 
Vincristine 1963 ALL, HL, NHL CLL, MM 1.4 mg/m2 IV 13.090/mg 26 

ALL indicates acute lymphocytic leukemia; AML, acute myelogenous leukemia; CLL, chronic lymphocytic leukemia; CML, chronic myelogenous leukemia; MM, multiple myeloma; IV, intravenous; PO, per os (oral); and AUC, area under the curve.

*

AWP indicates average wholesale price in US dollars based on data from the Red Book 2010. When multiple package sizes and manufacturers were listed, an average of all AWPs was used.

†

AWP per dose assumes a body surface area of 2 m2 and weight of 80 kg. Calculation for carboplatin is based on a maximum dose of 800 mg corresponding to a creatinine clearance of 135 mL/min. Calculation for vincristine is based on a maximum dose of 2 mg.

View Large
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal