Table 1 Phenotype and function of mouse... | American Society of Hematology

Table 1

Phenotype and function of mouse conventional DC subsets

Organ	Phenotype	Location	Function and characteristics
Lymphoid-tissue resident DCs
Spleen	CD8α⁺CD205⁺	T-cell area and marginal zone	Uptake and cross-presentation of Ag from apoptotic cells on MHC class I
	CD8α⁻33D1⁺	Red pulp and bridging channels	Predominant population; uptake and presentation of Ag on MHC class II
Thymus	CD8α⁺	Medulla	Predominant population; cross-presentation of Ag; self-tolerance
	CD8α⁻	Cortex, medulla, corticomedullary junction	Self-tolerance
LN	CD8α⁺	Cortex	Viral and self-Ag immunity; cross-presentation of Ag
	CD8α⁻	Cortex	Unknown
Migratory DCs
Skin	Langerin⁺ LC	Epidermis	Self-renew in situ, radiation resistant
	CD103⁺CD11b^lo+ Langerin⁺	Dermis	Viral and self-Ag immunity; cross-presentation of Ag
	CD103⁻CD11b^hi− Langerin⁻	Dermis	Unknown
Intestine	CD103⁺CD11b^lo	Peyer patches	Unknown
	CD103⁺CD11b⁺	Lamina propria	Transfer pathogenic bacteria from gut to mesenteric LN
	CD103⁻CD11b^hi	Lamina propria	Transport Ag to mesenteric LN from gut lumen
LN	CD11c^intCD40^hiMHCII^hiCCR7⁺	Cortex	Transport Ag to LN from periphery

Organ	Phenotype	Location	Function and characteristics
Lymphoid-tissue resident DCs
Spleen	CD8α⁺CD205⁺	T-cell area and marginal zone	Uptake and cross-presentation of Ag from apoptotic cells on MHC class I
	CD8α⁻33D1⁺	Red pulp and bridging channels	Predominant population; uptake and presentation of Ag on MHC class II
Thymus	CD8α⁺	Medulla	Predominant population; cross-presentation of Ag; self-tolerance
	CD8α⁻	Cortex, medulla, corticomedullary junction	Self-tolerance
LN	CD8α⁺	Cortex	Viral and self-Ag immunity; cross-presentation of Ag
	CD8α⁻	Cortex	Unknown
Migratory DCs
Skin	Langerin⁺ LC	Epidermis	Self-renew in situ, radiation resistant
	CD103⁺CD11b^lo+ Langerin⁺	Dermis	Viral and self-Ag immunity; cross-presentation of Ag
	CD103⁻CD11b^hi− Langerin⁻	Dermis	Unknown
Intestine	CD103⁺CD11b^lo	Peyer patches	Unknown
	CD103⁺CD11b⁺	Lamina propria	Transfer pathogenic bacteria from gut to mesenteric LN
	CD103⁻CD11b^hi	Lamina propria	Transport Ag to mesenteric LN from gut lumen
LN	CD11c^intCD40^hiMHCII^hiCCR7⁺	Cortex	Transport Ag to LN from periphery

LN indicates lymph node.