Table 2 Genes differentially expressed... | American Society of Hematology

Table 2

Genes differentially expressed on 8 hours of prednisolone exposure in this study and previously reported in the literature

Gene	Up- or down-regulation			Cell lines studied‡	References
Gene	Child ALL*	Lymphoid cell lines†	Nonleukemic cell lines†	Cell lines studied‡	References
ZFP36L2	Up	Up	—	697	Yoshida et al¹¹
FKBP5	Up	Up	—	697, Jurkat, CEM	Obexer et al,⁹ Planey et al,¹⁰ Yoshida et al¹¹
LIMK2	Up	Up	—	CEM	Medh et al,⁴⁰ Webb et al⁴⁵
NFIL3	Up	Up	—	CEM	Medh et al,⁴⁰ Webb et al⁴⁵
ISG20	Up	Up	—	697	Yoshida et al¹¹
TXNIP	Up	Up	—	697, CEM	Tonko et al,⁸ Planey et al,¹⁰ Medh et al,⁴⁰ Webb et al⁴⁵
C18ORF1	Up	Up	—	CEM	Tonko et al,⁸ Webb et al⁴⁵
BTEB1	Up	Up	—	697	Planey et al¹⁰
DUSP1 (MKP-1)	Up	Down§	—	697	Planey et al¹⁰
DSIP1 (GILZ)	Up	Up	—	697, CEM	Tonko et al,⁸ Planey et al¹⁰
BTG1	Up	Up	—	WEHI7.2, S49.A2, CEM, 697	Yoshida et al,¹¹ Wang et al,¹² Medh et al,⁴⁰ Webb et al⁴⁵
ZBTB16	Up	Up	—	CEM	Tonko et al⁸
SNF1LK	Up	Up	—	697	Yoshida et al¹¹
TUBA1	Up	Up	—	CEM	Medh et al,⁴⁰ Webb et al⁴⁵
DUSP10 (MKP-5)	Up	Down	—	697	Planey et al¹⁰
PGKI	Up	Down	—	CEM	Tonko et al⁸
SGK	Up	Up	—	WEHI7.2, S49.A2	Wang et al¹²
PRG1	Up	Up	—	CEM, 697	Planey et al,¹⁰ Medh et al,⁴⁰ Webb et al⁴⁵
EIF2C2	Up	Down	—	CEM	Medh et al,³⁹ Leong et al⁴⁴
PFKP	Up	Down	—	WEHI7.2, S49.A2	Wang et al¹²
BYSL	Down	Down	—	CEM	Tsai et al⁴
SOCS1	Up	Up	—	CEM, 697	Tonko et al,⁸ Yoshida et al,¹¹ Medh et al,⁴⁰ Webb et al⁴⁵
MAP2K1	Up	—	Up	Human bone marrow stromal cells (TM5)	Jeon et al⁴⁶
SDC2	Up	—	Up	Human glomerular epithelial cells	Kasinath et al⁴⁷
CEBPD	Up	—	Up	Different rat and rabbit cell types	Ramji and Foka⁴⁸
GK	Up	—	Up	Rat adipocytes	Taylor et al⁴⁹
STAT1	Down	—	Down	Human peripheral blood mononuclear cells	Hu et al⁵⁰
INSR	Up	—	Up	Human promonocytic cells	Leal et al⁵¹
CYP1A1	Down	—	Up	Human aorta endothelial cells	Celander et al⁵²

Gene	Up- or down-regulation			Cell lines studied‡	References
Gene	Child ALL*	Lymphoid cell lines†	Nonleukemic cell lines†	Cell lines studied‡	References
ZFP36L2	Up	Up	—	697	Yoshida et al¹¹
FKBP5	Up	Up	—	697, Jurkat, CEM	Obexer et al,⁹ Planey et al,¹⁰ Yoshida et al¹¹
LIMK2	Up	Up	—	CEM	Medh et al,⁴⁰ Webb et al⁴⁵
NFIL3	Up	Up	—	CEM	Medh et al,⁴⁰ Webb et al⁴⁵
ISG20	Up	Up	—	697	Yoshida et al¹¹
TXNIP	Up	Up	—	697, CEM	Tonko et al,⁸ Planey et al,¹⁰ Medh et al,⁴⁰ Webb et al⁴⁵
C18ORF1	Up	Up	—	CEM	Tonko et al,⁸ Webb et al⁴⁵
BTEB1	Up	Up	—	697	Planey et al¹⁰
DUSP1 (MKP-1)	Up	Down§	—	697	Planey et al¹⁰
DSIP1 (GILZ)	Up	Up	—	697, CEM	Tonko et al,⁸ Planey et al¹⁰
BTG1	Up	Up	—	WEHI7.2, S49.A2, CEM, 697	Yoshida et al,¹¹ Wang et al,¹² Medh et al,⁴⁰ Webb et al⁴⁵
ZBTB16	Up	Up	—	CEM	Tonko et al⁸
SNF1LK	Up	Up	—	697	Yoshida et al¹¹
TUBA1	Up	Up	—	CEM	Medh et al,⁴⁰ Webb et al⁴⁵
DUSP10 (MKP-5)	Up	Down	—	697	Planey et al¹⁰
PGKI	Up	Down	—	CEM	Tonko et al⁸
SGK	Up	Up	—	WEHI7.2, S49.A2	Wang et al¹²
PRG1	Up	Up	—	CEM, 697	Planey et al,¹⁰ Medh et al,⁴⁰ Webb et al⁴⁵
EIF2C2	Up	Down	—	CEM	Medh et al,³⁹ Leong et al⁴⁴
PFKP	Up	Down	—	WEHI7.2, S49.A2	Wang et al¹²
BYSL	Down	Down	—	CEM	Tsai et al⁴
SOCS1	Up	Up	—	CEM, 697	Tonko et al,⁸ Yoshida et al,¹¹ Medh et al,⁴⁰ Webb et al⁴⁵
MAP2K1	Up	—	Up	Human bone marrow stromal cells (TM5)	Jeon et al⁴⁶
SDC2	Up	—	Up	Human glomerular epithelial cells	Kasinath et al⁴⁷
CEBPD	Up	—	Up	Different rat and rabbit cell types	Ramji and Foka⁴⁸
GK	Up	—	Up	Rat adipocytes	Taylor et al⁴⁹
STAT1	Down	—	Down	Human peripheral blood mononuclear cells	Hu et al⁵⁰
INSR	Up	—	Up	Human promonocytic cells	Leal et al⁵¹
CYP1A1	Down	—	Up	Human aorta endothelial cells	Celander et al⁵²

— indicates not applicable.

From this study.

†

From the literature.

‡

697 indicates human pre-B leukemia cell line; Jurkat, T-lineage leukemic cell line; CEM, T-lineage leukemic cell line; WEH17.2, T-cell lymphoma cell line; S49A2, T-cell lymphoma cell line.

Up-regulation reported in nonleukemic cell lines.⁵³

View Large

This Feature Is Available To Subscribers Only