Table 3 Biological functions of... | American Society of Hematology

Table 3

Biological functions of prednisolone-responsive genes in pediatric ALL

Function	Genes
Proapoptotic	ADORA2A,*NFIL3, ZBTB16, STAT1,*ISG20, TXN1P, BTG1, RARRES3,*SOCS1, DSIP1 (GILZ)
Proliferation	ADORA2A,*NFIL3, ZBTB16, ZFP36L2, MAP2K1, CEBPD, DUSP1 (MKP-1), NMT2,*RNF111, DUSP10 (MKP-5), TNFAIP3, SGK, IMP-3
Metabolism	CYP1A1,†GM2A,‡IRS2,§GK,^§INSR,§PGK1,§PFKP,§SGK*§
Other	FKBP5, LIMK2, MYH9, SLC29A3, CEBPD, KLF9, NQO2,*SPON2, CSNK1D, SNF1LK, IGHG1,*TUBA1, NLGN4X,PRG1, EIF2C2, GABPB2, MRPS16
Unknown	KCTD12, C18ORF1, SDC2, RNF38, BYSL,THEM43, NUDT18

Function	Genes
Proapoptotic	ADORA2A,*NFIL3, ZBTB16, STAT1,*ISG20, TXN1P, BTG1, RARRES3,*SOCS1, DSIP1 (GILZ)
Proliferation	ADORA2A,*NFIL3, ZBTB16, ZFP36L2, MAP2K1, CEBPD, DUSP1 (MKP-1), NMT2,*RNF111, DUSP10 (MKP-5), TNFAIP3, SGK, IMP-3
Metabolism	CYP1A1,†GM2A,‡IRS2,§GK,^§INSR,§PGK1,§PFKP,§SGK*§
Other	FKBP5, LIMK2, MYH9, SLC29A3, CEBPD, KLF9, NQO2,*SPON2, CSNK1D, SNF1LK, IGHG1,*TUBA1, NLGN4X,PRG1, EIF2C2, GABPB2, MRPS16
Unknown	KCTD12, C18ORF1, SDC2, RNF38, BYSL,THEM43, NUDT18

The function of the different genes was studied in the literature (PubMed search). Some genes have multiple functions, depending on cell type, stage in cell cycle.

Genes down-regulated on glucocorticoid exposure.

†

Drug-metabolizing enzyme.

‡

Glycosphingolipid metabolism.

Carbohydrate metabolism

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