Transcription factor-binding motifs in prednisolone-responsive genes
| Transcription factor . | TBFM matrix . | Fold difference* . | P . |
|---|---|---|---|
| Overrepresented | |||
| cAMP-responsive element-binding protein | V$CREB_Q2 | 2.8 | < .001 |
| CRE-binding protein 1 | V$CREBP1_Q2 | 2.8 | .006 |
| cAMP-responsive element-binding protein | V$CREB_02 | 2.5 | < .001 |
| Activator protein 2 | V$AP2_Q6 | 2.5 | < .001 |
| cAMP-responsive element-binding protein | V$CREB_01 | 2.5 | .003 |
| cAMP-responsive element-binding protein | V$CREB_Q4 | 2.2 | .006 |
| Stimulating protein 1 | V$SP1_Q6 | 2.1 | < .001 |
| GC box elements | V$GC_01 | 1.9 | .002 |
| MZF1 | V$MZF1_01 | 1.6 | <.001 |
| Stimulating protein 1 | V$SP1_01 | 1.6 | .004 |
| Activator protein 4 | V$AP4_Q5 | 1.4 | .006 |
| Underrepresented | |||
| YY1 (yin and yang 1) | V$YY1_01 | −2.5 | < .001 |
| Octamer factor 1 | V$OCT1_03 | −2.0 | .002 |
| GATA-binding factor 3 | V$GATA3_01 | −1.4 | .007 |
| GATA-binding factor 1 | V$GATA1_01 | −1.3 | .002 |
| GATA-binding factor 2 | V$GATA2_01 | −1.3 | .004 |
| Cap signal for transcription initiation | V$CAP_01 | −1.1 | < .001 |
| Transcription factor . | TBFM matrix . | Fold difference* . | P . |
|---|---|---|---|
| Overrepresented | |||
| cAMP-responsive element-binding protein | V$CREB_Q2 | 2.8 | < .001 |
| CRE-binding protein 1 | V$CREBP1_Q2 | 2.8 | .006 |
| cAMP-responsive element-binding protein | V$CREB_02 | 2.5 | < .001 |
| Activator protein 2 | V$AP2_Q6 | 2.5 | < .001 |
| cAMP-responsive element-binding protein | V$CREB_01 | 2.5 | .003 |
| cAMP-responsive element-binding protein | V$CREB_Q4 | 2.2 | .006 |
| Stimulating protein 1 | V$SP1_Q6 | 2.1 | < .001 |
| GC box elements | V$GC_01 | 1.9 | .002 |
| MZF1 | V$MZF1_01 | 1.6 | <.001 |
| Stimulating protein 1 | V$SP1_01 | 1.6 | .004 |
| Activator protein 4 | V$AP4_Q5 | 1.4 | .006 |
| Underrepresented | |||
| YY1 (yin and yang 1) | V$YY1_01 | −2.5 | < .001 |
| Octamer factor 1 | V$OCT1_03 | −2.0 | .002 |
| GATA-binding factor 3 | V$GATA3_01 | −1.4 | .007 |
| GATA-binding factor 1 | V$GATA1_01 | −1.3 | .002 |
| GATA-binding factor 2 | V$GATA2_01 | −1.3 | .004 |
| Cap signal for transcription initiation | V$CAP_01 | −1.1 | < .001 |
Transcription factor binding motifs (TFBMs) overrepresented and underrepresented in 39 genes up-regulated on 8 hours of prednisolone exposure.
Fold difference in the frequency of specified TFBMs in up-regulated genes compared with the frequency observed in genes that are not differentially expressed on prednisolone exposure.