Morphological analysis by μCT of femurs from μMT/μMT B-cell KO mice and WT controls
| Morphological parameters . | WT mice . | B-cell KO mice . | % change . | P . |
|---|---|---|---|---|
| TV, mm3 | 1.28 ± 0.06 | 1.29 ± 0.07 | 0.8 | ≤ .685 |
| BV, mm3 | 0.30 ± 0.03 | 0.25 ± 0.28 | −16.7 | ≤ .003* |
| BV/TV, % | 23.96 ± 2.76 | 19.87 ± 2.51 | −17.1 | ≤ .008* |
| Tb. Th., μm | 60.49 ± 2.78 | 56.21 ± 5.09 | −7.1 | ≤ .011* |
| Tb. Sp., μm | 222.23 ± 7.99 | 244.45 ± 13.66 | 10.0 | ≤ .001* |
| Tb. N./mm | 4.54 ± 0.16 | 4.17 ± 0.19 | −8.1 | ≤ .001* |
| SMI | 0.69 ± 0.24 | 0.79 ± 0.21 | 14.5 | ≤ .402 |
| Conn. D./mm3 | 133.48 ± 15.85 | 102.62 ± 18.46 | −23.1 | ≤ .003* |
| Co. Th., μm | 91.1 ± 3.1 | 82.9 ± 8.4 | −9.0 | ≤ .002* |
| Co. Vol., mm3 | 0.47 ± 0.03 | 0.42 ± 0.04 | −10.6 | ≤ .010* |
| Morphological parameters . | WT mice . | B-cell KO mice . | % change . | P . |
|---|---|---|---|---|
| TV, mm3 | 1.28 ± 0.06 | 1.29 ± 0.07 | 0.8 | ≤ .685 |
| BV, mm3 | 0.30 ± 0.03 | 0.25 ± 0.28 | −16.7 | ≤ .003* |
| BV/TV, % | 23.96 ± 2.76 | 19.87 ± 2.51 | −17.1 | ≤ .008* |
| Tb. Th., μm | 60.49 ± 2.78 | 56.21 ± 5.09 | −7.1 | ≤ .011* |
| Tb. Sp., μm | 222.23 ± 7.99 | 244.45 ± 13.66 | 10.0 | ≤ .001* |
| Tb. N./mm | 4.54 ± 0.16 | 4.17 ± 0.19 | −8.1 | ≤ .001* |
| SMI | 0.69 ± 0.24 | 0.79 ± 0.21 | 14.5 | ≤ .402 |
| Conn. D./mm3 | 133.48 ± 15.85 | 102.62 ± 18.46 | −23.1 | ≤ .003* |
| Co. Th., μm | 91.1 ± 3.1 | 82.9 ± 8.4 | −9.0 | ≤ .002* |
| Co. Vol., mm3 | 0.47 ± 0.03 | 0.42 ± 0.04 | −10.6 | ≤ .010* |
Trabecular indices, including TV, BV, BV/TV, Tb. Th., Tb. Sp., Tb. N., SMI, and Conn. D., and the cortical indices Co. Th. and Co. Vol. were computed from μCT scans. The data are presented as the mean ± SD of 8 mice per group. Percentage change between WT and KO mice is indicated as “% change.” Asterisks indicate significantly different results (P ≤ .05).