Morphological analysis by μCT of tibias from nude mice and WT controls
| Morphological parameters . | WT mice . | Nude mice . | % change . | P . |
|---|---|---|---|---|
| TV, mm3 | 1.27 ± 0.15 | 1.28 ± 0.08 | 0.8 | ≤ .870 |
| BV, mm3 | 0.20 ± 0.04 | 0.17 ± 0.03 | −15.0 | ≤ .046* |
| BV/TV, % | 15.8 ± 1.18 | 13.1 ± 1.88 | −17.1 | ≤ .004* |
| Tb. Th., μm | 46.0 ± 2.11 | 41.1 ± 1.95 | −10.7 | ≤ .001* |
| Tb. Sp., μm | 192.1 ± 19.5 | 193.8 ± 11.5 | 0.9 | ≤ .835 |
| Tb. N./mm | 5.33 ± 0.46 | 5.24 ± 0.27 | −1.7 | ≤ .641 |
| SMI | 2.08 ± 0.13 | 2.3 ± 0.10 | 10.6 | ≤ .002* |
| Conn. D./mm3 | 242.2 ± 26.8 | 215.4 ± 39.8 | −11.1 | ≤ .137 |
| Co. Th., μm | 83.7 ± 2.2 | 73.8 ± 2.1 | −11.8 | ≤ .001* |
| Co. Vol., mm3 | 0.29 ± 0.03 | 0.17 ± 0.02 | −41.1 | ≤ .001* |
| Morphological parameters . | WT mice . | Nude mice . | % change . | P . |
|---|---|---|---|---|
| TV, mm3 | 1.27 ± 0.15 | 1.28 ± 0.08 | 0.8 | ≤ .870 |
| BV, mm3 | 0.20 ± 0.04 | 0.17 ± 0.03 | −15.0 | ≤ .046* |
| BV/TV, % | 15.8 ± 1.18 | 13.1 ± 1.88 | −17.1 | ≤ .004* |
| Tb. Th., μm | 46.0 ± 2.11 | 41.1 ± 1.95 | −10.7 | ≤ .001* |
| Tb. Sp., μm | 192.1 ± 19.5 | 193.8 ± 11.5 | 0.9 | ≤ .835 |
| Tb. N./mm | 5.33 ± 0.46 | 5.24 ± 0.27 | −1.7 | ≤ .641 |
| SMI | 2.08 ± 0.13 | 2.3 ± 0.10 | 10.6 | ≤ .002* |
| Conn. D./mm3 | 242.2 ± 26.8 | 215.4 ± 39.8 | −11.1 | ≤ .137 |
| Co. Th., μm | 83.7 ± 2.2 | 73.8 ± 2.1 | −11.8 | ≤ .001* |
| Co. Vol., mm3 | 0.29 ± 0.03 | 0.17 ± 0.02 | −41.1 | ≤ .001* |
Trabecular indices, including TV, BV, BV/TV, Tb. Th., Tb. Sp., Tb. N., SMI, and Conn. D., and the cortical indices Co. Th. and Co. Vol. were computed from μCT scans. The data are presented as the mean ± SD of 8 mice per group. Percentage change between WT and nude mice is indicated as “% change.” Asterisks indicate significantly different results (P ≤ .05).