Morphological analysis by μCT of femurs from CD40 mice compared with respective WT mice
| Morphological parameters . | WT mice . | CD40 KO mice . | % change . | P . |
|---|---|---|---|---|
| TV, mm3 | 1.29 ± 0.06 | 1.23 ± 0.13 | −4.7 | ≤ .158 |
| BV, mm3 | 0.32 ± 0.03 | 0.26 ± 0.03 | −18.8 | ≤ .001* |
| BV/TV, % | 24.47 ± 2.26 | 21.67 ± 2.55 | −11.4 | ≤ .008* |
| Tb. Th., μm | 73.07 ± 3.87 | 66.24 ± 5.83 | −9.3 | ≤ .002* |
| Tb. Sp., μm | 252.66 ± 15.66 | 252.94 ± 19.59 | 0.1 | ≤ .969 |
| Tb. N./mm | 4.13 ± 0.24 | 4.17 ± 0.15 | 1.0 | ≤ .619 |
| SMI | 0.47 ± 0.17 | 0.64 ± 0.15 | 36.2 | ≤ .014* |
| Conn. D./mm3 | 73.9 ± 14.5 | 85.3 ± 15.4 | 15.4 | ≤ .070 |
| Co. Th., μm | 106.3 ± 5.5 | 102.3 ± 5.1 | −3.8 | ≤ .072 |
| Co. Vol., μm | 0.56 ± 0.03 | 0.53 ± 0.03 | −5.4 | ≤ .020* |
| Morphological parameters . | WT mice . | CD40 KO mice . | % change . | P . |
|---|---|---|---|---|
| TV, mm3 | 1.29 ± 0.06 | 1.23 ± 0.13 | −4.7 | ≤ .158 |
| BV, mm3 | 0.32 ± 0.03 | 0.26 ± 0.03 | −18.8 | ≤ .001* |
| BV/TV, % | 24.47 ± 2.26 | 21.67 ± 2.55 | −11.4 | ≤ .008* |
| Tb. Th., μm | 73.07 ± 3.87 | 66.24 ± 5.83 | −9.3 | ≤ .002* |
| Tb. Sp., μm | 252.66 ± 15.66 | 252.94 ± 19.59 | 0.1 | ≤ .969 |
| Tb. N./mm | 4.13 ± 0.24 | 4.17 ± 0.15 | 1.0 | ≤ .619 |
| SMI | 0.47 ± 0.17 | 0.64 ± 0.15 | 36.2 | ≤ .014* |
| Conn. D./mm3 | 73.9 ± 14.5 | 85.3 ± 15.4 | 15.4 | ≤ .070 |
| Co. Th., μm | 106.3 ± 5.5 | 102.3 ± 5.1 | −3.8 | ≤ .072 |
| Co. Vol., μm | 0.56 ± 0.03 | 0.53 ± 0.03 | −5.4 | ≤ .020* |
Trabecular indices, including TV, BV, BV/TV, Tb. Th., Tb. Sp., Tb. N., SMI, and Conn. D., and the cortical indices Co. Th. and Co. Vol. were computed from μCT scans of CD40 KO mice and their respective WT controls. The data are presented as the mean ± SD. Percentage change between WT and KO mice is indicated as “% change.” Asterisks indicate significantly different results (P ≤ .05); n = 12 WT and 13 CD40 KO mice.