Morphological analysis by μCT of femurs from CD40L KO mice compared with respective WT mice
| Morphological parameters . | WT mice . | CD40L KO mice . | % change . | P . |
|---|---|---|---|---|
| TV, mm3 | 1.19 ± 0.05 | 1.17 ± 0.11 | −1.7 | ≤ .570 |
| BV, mm3 | 0.29 ± 0.02 | 0.19 ± 0.029 | −34.5 | ≤ .001* |
| BV/TV, % | 24.37 ± 1.66 | 16.24 ± 1.67 | −33.4 | ≤ .001* |
| Tb. Th., μm | 67.94 ± 2.99 | 63.57 ± 3.05 | −6.4 | ≤ .002* |
| Tb. Sp., μm | 230.14 ± 13.49 | 272.90 ± 18.39 | 18.6 | ≤ .001* |
| Tb. N./mm | 4.37 ± 0.19 | 3.91 ± 0.26 | −10.5 | ≤ .001* |
| SMI | 0.59 ± 0.11 | 1.11 ± 0.19 | 88.1 | ≤ .001* |
| Conn. D./mm3 | 90.10 ± 12.97 | 57.00 ± 8.94 | −36.7 | ≤ .001* |
| Co. Th., μm | 100.6 ± 4.5 | 94.3 ± 7.2 | −6.3 | ≤ .016* |
| Co. Vol., μm | 0.51 ± 0.03 | 0.48 ± 0.04 | −5.9 | ≤ .046* |
| Morphological parameters . | WT mice . | CD40L KO mice . | % change . | P . |
|---|---|---|---|---|
| TV, mm3 | 1.19 ± 0.05 | 1.17 ± 0.11 | −1.7 | ≤ .570 |
| BV, mm3 | 0.29 ± 0.02 | 0.19 ± 0.029 | −34.5 | ≤ .001* |
| BV/TV, % | 24.37 ± 1.66 | 16.24 ± 1.67 | −33.4 | ≤ .001* |
| Tb. Th., μm | 67.94 ± 2.99 | 63.57 ± 3.05 | −6.4 | ≤ .002* |
| Tb. Sp., μm | 230.14 ± 13.49 | 272.90 ± 18.39 | 18.6 | ≤ .001* |
| Tb. N./mm | 4.37 ± 0.19 | 3.91 ± 0.26 | −10.5 | ≤ .001* |
| SMI | 0.59 ± 0.11 | 1.11 ± 0.19 | 88.1 | ≤ .001* |
| Conn. D./mm3 | 90.10 ± 12.97 | 57.00 ± 8.94 | −36.7 | ≤ .001* |
| Co. Th., μm | 100.6 ± 4.5 | 94.3 ± 7.2 | −6.3 | ≤ .016* |
| Co. Vol., μm | 0.51 ± 0.03 | 0.48 ± 0.04 | −5.9 | ≤ .046* |
Trabecular indices, including TV, BV, BV/TV, Tb. Th., Tb. Sp., Tb. N., SMI, and Conn. D., and the cortical indices Co. Th. and Co. Vol. were computed from μCT scans of CD40 and CD40L KO mice and their respective WT controls. The data are presented as the mean ± SD. Percentage change between WT and KO mice is indicated as “% change.” Asterisks indicate significantly different results (P ≤ .05); n = 11 mice per group for CD40L KO and WT mice.