Transporters identified in platelets
| Transporter . | Localization . | Proposed substrates . | Reference(s) . |
|---|---|---|---|
| ABC transporters | |||
| ABCA7 | Plasma membrane | Cholesterol, lipid mediators (?) | 29,52 |
| ABCB4 (MDR3) | Plasma membrane | Phospholipids, lipid mediators (?) | 29 |
| ABCC1 (MRP1) | Plasma membrane | Amphiphilic anions, glutathione, LTC4 | 29,49 |
| ABCC3 (MRP3) | Plasma membrane | Amphiphilic anions, LTC4 | 29 |
| ABCC4 (MRP4) | Dense granules, plasma membrane | Amphiphilic anions, purine nucleotide–based mediators; glutathione, lipid mediators | 10,14,15,29 |
| SLC transporters | |||
| SLC1A1 (EAAT3) | Plasma membrane | Glutamate and neutral amino acids | 19 |
| SLC6A4 (SERT) | Plasma membrane | Serotonin, monamine transmitter | 18,74,75 |
| SLC6A12 (BGT-1) | Plasma membrane | Betaine, GABA | 19 |
| SLC18A2 (VMAT2) | Dense granules | Serotonin, monamine transmitter | 85,–87 |
| SLC21/SLCO2B1 (OATP2B1) | Plasma membrane | Amphiphilic anions, statins | 21 |
| SLC23A2 (SVCT2) | Plasma membrane | Ascorbic acid | 88,89 |
| SLC35d3 | Dense tubular system (?) | Nucleotide sugars (?) | 90,91 |
| SLC44A2 (CTL-2) | Granules (?) | Choline (?) | 27,28 |
| Transporter . | Localization . | Proposed substrates . | Reference(s) . |
|---|---|---|---|
| ABC transporters | |||
| ABCA7 | Plasma membrane | Cholesterol, lipid mediators (?) | 29,52 |
| ABCB4 (MDR3) | Plasma membrane | Phospholipids, lipid mediators (?) | 29 |
| ABCC1 (MRP1) | Plasma membrane | Amphiphilic anions, glutathione, LTC4 | 29,49 |
| ABCC3 (MRP3) | Plasma membrane | Amphiphilic anions, LTC4 | 29 |
| ABCC4 (MRP4) | Dense granules, plasma membrane | Amphiphilic anions, purine nucleotide–based mediators; glutathione, lipid mediators | 10,14,15,29 |
| SLC transporters | |||
| SLC1A1 (EAAT3) | Plasma membrane | Glutamate and neutral amino acids | 19 |
| SLC6A4 (SERT) | Plasma membrane | Serotonin, monamine transmitter | 18,74,75 |
| SLC6A12 (BGT-1) | Plasma membrane | Betaine, GABA | 19 |
| SLC18A2 (VMAT2) | Dense granules | Serotonin, monamine transmitter | 85,–87 |
| SLC21/SLCO2B1 (OATP2B1) | Plasma membrane | Amphiphilic anions, statins | 21 |
| SLC23A2 (SVCT2) | Plasma membrane | Ascorbic acid | 88,89 |
| SLC35d3 | Dense tubular system (?) | Nucleotide sugars (?) | 90,91 |
| SLC44A2 (CTL-2) | Granules (?) | Choline (?) | 27,28 |
(?) indicates putative (unproven) substrate or localization.